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    CG9426 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34719, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9426provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032485
    Locus tag
    Dmel_CG9426
    See related
    AllianceGenome:FB:FBgn0032485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9426; Ipp
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in larval muscle system; larval somatic muscle cell; and organism. Orthologous to human IPP (intracisternal A particle-promoted polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9426 in Genome Data Viewer
    Location:
    34A10-34A10; 2-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13216290..13219923, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13216290..13219923, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene kekkon 4 Neighboring gene small nuclear RNA U2 at 34AB b Neighboring gene mitochondrial translation release factor 1 Neighboring gene Ski6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila. Arama E, et al. PLoS Biol, 2007 Oct. PMID 17880263, Free PMC Article
    2. Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary. Soshnev AA, et al. Nucleic Acids Res, 2012 Jul. PMID 22406832, Free PMC Article
    3. Flying through the drosophila cytoskeletal genome. Goldstein LS, et al. J Cell Biol, 2000 Jul 24. PMID 10908588, Free PMC Article
    4. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article
    5. A protein network-guided screen for cell cycle regulators in Drosophila. Guest ST, et al. BMC Syst Biol, 2011 May 6. PMID 21548953, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9426-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13216290..13219923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135772.2 → NP_609616.1  uncharacterized protein Dmel_CG9426 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK21
      Related
      FBpp0080063
      Conserved Domains (7) summary
      smart00612
      Location:385 → 431
      Kelch; Kelch domain
      PHA03098
      Location:78 → 558
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:468 → 512
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:73 → 179
      BTB; BTB/POZ domain
      pfam01344
      Location:515 → 557
      Kelch_1; Kelch motif
      pfam07707
      Location:187 → 289
      BACK; BTB And C-terminal Kelch
      pfam13964
      Location:467 → 516
      Kelch_6; Kelch motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK21 Q9VK21

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