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    Inx6 Innexin 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inx6provided by FlyBase
    Official Full Name
    Innexin 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0027107
    Locus tag
    Dmel_CG17063
    See related
    AllianceGenome:FB:FBgn0027107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17063; Dm-inx6; Dmel\CG17063; FBpp0077031; inx-6; inx6; prp6
    Summary
    Predicted to enable gap junction channel activity. Involved in medium-term memory. Located in gap junction. Is expressed in adult brain; fan-shaped body; and pedunculus of adult mushroom body. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Inx6 in Genome Data Viewer
    Location:
    19C1-19C1; 1-64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20267821..20269769, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20138847..20140795, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45504 Neighboring gene long non-coding RNA:CR45505

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness. Troup M, et al. Elife, 2018 Aug 15. PMID 30109983, Free PMC Article
    2. Recent findings in evolution and function of insect innexins. Hasegawa DK, et al. FEBS Lett, 2014 Apr 17. PMID 24631533
    3. Drosophila has several genes for gap junction proteins. Curtin KD, et al. Gene, 1999 May 31. PMID 10352230
    4. Gap junction protein Innexin2 modulates the period of free-running rhythms in Drosophila melanogaster. Ramakrishnan A, et al. iScience, 2021 Sep 24. PMID 34522854, Free PMC Article
    5. Anatomical distribution and functional roles of electrical synapses in Drosophila. Ammer G, et al. Curr Biol, 2022 May 9. PMID 35385694

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intercellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    innexin 6
    Names
    CG17063-PA
    Inx6-PA
    inx6
    pas related protein 6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20267821..20269769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132146.2 → NP_572374.1  innexin 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572374.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9UA15, Q9VR82
      Related
      FBpp0077031
      Conserved Domains (1) summary
      pfam00876
      Location:21 → 389
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VR82.1 Q9VR82

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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