mnb minibrain [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mnbprovided by FlyBase
Official Full Name: minibrainprovided by FlyBase
Primary source: FLYBASE:FBgn0259168
Locus tag: Dmel_CG42273
See related: AllianceGenome:FB:FBgn0259168
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG42273; CG7826; CG7835; Dm1; DmDyrk1A; Dmel\CG42273; Dyrk1; DYRK1; Dyrk1a; Dyrk1A; DYRK1A; ME-IV; min; Minibrain; Mnb; MNB
Old locus tag: Dmel_CG7826; Dmel_CG7835
Summary: Enables protein kinase inhibitor activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of hippo signaling; olfactory learning; and positive regulation of developmental growth. Located in terminal bouton. Is expressed in several structures, including adult brain; adult mushroom body beta-lobe; embryonic/larval optic lobe; ganglia; and larval central brain. Used to study Down syndrome and syndromic intellectual disability. Human ortholog(s) of this gene implicated in Down syndrome; abdominal obesity-metabolic syndrome 3; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to several human genes including DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 16E2-16F1; 1-59 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (17862697..17887222, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (17756730..17781255, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity.
Title: DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity.
Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation.
Title: Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation.
Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.
Title: Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.
This study demonstrated that neuronal overexpression of mnb, the Drosophila ortholog of DYRK1A, is sufficient to induce motor impairment, accelerate age-related decline in motor performance, shorten lifespan and cause age-dependent neurodegeneration
Title: Neuronal overexpression of Alzheimer's disease and Down's syndrome associated DYRK1A/minibrain gene alters motor decline, neurodegeneration and synaptic plasticity in Drosophila.
We propose that Mnb/Dyrk1A plays a central role in central nervous system neurogenesis by integrating molecular mechanisms that regulate progenitor self-renewal, cell cycle progression and neuronal differentiation
Title: Mnb/Dyrk1A orchestrates a transcriptional network at the transition from self-renewing neurogenic progenitors to postmitotic neuronal precursors.
We have thus uncovered a previously unknown mechanism of down-regulation of Cic activity by Mnb and Wap, which operates independently from the ERK-mediated control of Cic. Therefore, Cic functions as an integrator of upstream signals that are essential for tissue patterning and organ growth
Title: Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua.
results demonstrate that phosphoregulation of microtubule dynamics by MNB/DYRK1a is critical for dendritic patterning and neuronal function
Title: Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.
Mnb is a synaptic kinase that promotes efficient synaptic vesicle recycling by Synj function at the neuromuscular junction.
Title: Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase.
the WD40 repeat protein Riquiqui (Riq) and the DYRK-family kinase Minibrain (Mnb)are two regulators of the Drosophila melanogaster SWH pathway that function downstream of Dachsous intracellular domains
Title: Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous.
Mnb/Dyrk1a regulates food intake through the evolutionary conserved Sir2-FOXO-sNPF/NPY pathway in Drosophila melanogaster and mammals.
Title: Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

stSG634340 (e-PCR)
- UniSTS:460011

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c17866676-17866569 mobile_element_type = transposon:INE-1{}4267

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in circadian rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in visual behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: minibrain

Names: CG42273-PE; CG42273-PF; CG42273-PG; CG42273-PH; CG42273-PI; Dual-specificity tyrosine phosphorylation-regulated kinase 1A; minibrain kinase; mnb-PE; mnb-PF; mnb-PG; mnb-PH; mnb-PI

NP_001014750.1

EC 2.7.11.1

EC 2.7.12.1

NP_001285393.1

EC 2.7.11.1

EC 2.7.12.1

NP_728104.1

EC 2.7.11.1

EC 2.7.12.1

NP_728106.1

EC 2.7.11.1

EC 2.7.12.1

NP_728107.2

EC 2.7.11.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

17862697..17887222 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167581.3 → NP_728104.1 minibrain, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728104.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P49657, Q59E39, Q6AWJ3, Q9I7R8, Q9VX07

Conserved Domains (2) summary

smart00220
Location:164 → 484

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:150 → 489

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_170659.2 → NP_728107.2 minibrain, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728107.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VX06

Conserved Domains (2) summary

smart00220
Location:303 → 623

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:289 → 628

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_001014750.2 → NP_001014750.1 minibrain, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014750.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P49657

Conserved Domains (2) summary

smart00220
Location:164 → 484

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:150 → 489

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_170658.3 → NP_728106.1 minibrain, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728106.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P49657

Conserved Domains (2) summary

smart00220
Location:164 → 484

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:150 → 489

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_001298464.1 → NP_001285393.1 minibrain, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285393.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JFM3

Conserved Domains (2) summary

smart00220
Location:303 → 623

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:289 → 628

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1