grk gurken [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: grkprovided by FlyBase
Official Full Name: gurkenprovided by FlyBase
Primary source: FLYBASE:FBgn0001137
Locus tag: Dmel_CG17610
See related: AllianceGenome:FB:FBgn0001137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17610; CT32746; Dmel\CG17610; Grk; GRK; Gurken; s-Grk
Summary: Enables epidermal growth factor receptor binding activity and receptor ligand activity. Involved in several processes, including dorsal appendage formation; positive regulation of border follicle cell migration; and regionalization. Located in extracellular space and plasma membrane. Is expressed in germarium region 2; germarium region 2b; nurse cell; oocyte; and ovary. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 29C4-29C4; 2-32 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (8431086..8433598, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (8431086..8433598, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sites phosphorylated by CK2 overlap with active Orb and with Gurken protein expression.
Title: Translational control of gurken mRNA in Drosophila development.
The study suggests that both the localization and the translation of gurken mRNA in the vitellarium is independent from Vasa.
Title: Combining the auxin-inducible degradation system with CRISPR/Cas9-based genome editing for the conditional depletion of endogenous Drosophila melanogaster proteins.
The translational regulation of gurken protein in nurse cells, where the transcript is synthesized, occurs by a different mechanism from that of oskar protein and bicoid protein mRNA in the oocyte.
Title: Localized Translation of gurken/TGF-α mRNA during Axis Specification Is Controlled by Access to Orb/CPEB on Processing Bodies.
Localized cytoplasmic polyadenylation of grk mRNA by Wisp and Orb is necessary to achieve appropriate Grk protein accumulation in the D/A corner of the oocyte during mid to late oogenesis.
Title: Wispy and Orb cooperate in the cytoplasmic polyadenylation of localized gurken mRNA.
reducing the function of eIF1A in spnB ovaries suppresses the ventralized eggshell phenotype by restoring Grk expression
Title: Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.
A new pathway is identified that mediates cell-type and branch-specific synaptic repulsion, a novel role for EGFR signaling in synaptic target selection, and an unexpected role for Gurken as a muscle-secreted repulsive ligand.
Title: EGFR signaling modulates synaptic connectivity via Gurken.
The Syx1A dependent trafficking of Grk protein is required for efficient EGFR signaling during dorsal-ventral patterning.
Title: Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking.
Reduced TOR activity promotes grk translation independent of the canonical Vasa RNA helicase and cap-dependent mechanism.
Title: Modulation of gurken translation by insulin and TOR signaling in Drosophila.
grk, a host gene encoding a crucial axis determinant, is a key component of an mRNP complex that regulates Wolbachia proliferation in Drosophila oogenesis.
Title: A feedback loop between Wolbachia and the Drosophila gurken mRNP complex influences Wolbachia titer.
Data indicate that trapping at the anterodorsal corner requires at least one as-yet-unidentified gurken RLE.
Title: Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification, follicular epithelium	TAS Traceable Author Statement more info	PubMed
involved_in anterior/posterior pattern specification	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chorion-containing eggshell pattern formation	HMP more info	PubMed
involved_in determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification, ovarian follicular epithelium	TAS Traceable Author Statement more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte anterior/posterior axis specification	TAS Traceable Author Statement more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte dorsal/ventral axis specification	TAS Traceable Author Statement more info	PubMed
involved_in oocyte microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed