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    Rsph1 Radial spoke head protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rsph1provided by FlyBase
    Official Full Name
    Radial spoke head protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032478
    Locus tag
    Dmel_CG5458
    See related
    AllianceGenome:FB:FBgn0032478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5458; Dmel\CG5458; dRSPH1
    Summary
    Involved in axoneme assembly. Predicted to be located in cytosol and nucleus. Is expressed in adult head; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and primary ciliary dyskinesia 24. Orthologous to human RSPH1 (radial spoke head component 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rsph1 in Genome Data Viewer
    Location:
    34A8-34A8; 2-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13183450..13184875)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13183450..13184875)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Neighboring gene uncharacterized protein Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene uncharacterized protein Neighboring gene Phosphoethanolamine cytidylyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RSBP15 interacts with and stabilizes dRSPH3 during sperm axoneme assembly in Drosophila. Wang Y, et al. J Genet Genomics, 2019 Jun 20. PMID 31281031
    2. Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors. Blümel L, et al. Cell Death Dis, 2022 Sep 20. PMID 36127323, Free PMC Article
    3. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article
    4. Structure and molecular basis of spermatid elongation in the Drosophila testis. Huang Q, et al. Open Biol, 2023 Nov. PMID 37935354, Free PMC Article
    5. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    radial spoke head protein 1
    Names
    CG5458-PA
    Rsph1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13183450..13184875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135765.4 → NP_609609.1  radial spoke head protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK29
      Related
      FBpp0080018
      Conserved Domains (2) summary
      smart00698
      Location:95 → 116
      MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
      pfam02493
      Location:51 → 73
      MORN; MORN repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK29 Q9VK29

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