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    kmg kumgang [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kmgprovided by FlyBase
    Official Full Name
    kumgangprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032473
    Locus tag
    Dmel_CG5204
    See related
    AllianceGenome:FB:FBgn0032473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.212; CG5204; Dmel\CG5204
    Summary
    Enables chromatin binding activity. Involved in regulation of gene expression and spermatogenesis. Located in nucleus. Is expressed in spermatocyte and testis. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 10. Orthologous to human ZFP64 (ZFP64 zinc finger protein) and ZNF335 (zinc finger protein 335). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kmg in Genome Data Viewer
    Location:
    34A7-34A7; 2-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13160527..13163153)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13160527..13163153)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44199 Neighboring gene Protein kinase at 34A Neighboring gene DnaJ homolog Neighboring gene Sirtuin 1 Neighboring gene Scm-related gene containing four mbt domains Neighboring gene antisense RNA:CR46256

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Kim J, et al. Science, 2017 May 19. PMID 28522526, Free PMC Article
    2. Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Rosenberg MI, et al. Cell, 2002 May 17. PMID 12086602
    3. A transposon expression burst accompanies the activation of Y-chromosome fertility genes during Drosophila spermatogenesis. Lawlor MA, et al. Nat Commun, 2021 Nov 25. PMID 34824217, Free PMC Article
    4. Developmentally regulated alternate 3' end cleavage of nascent transcripts controls dynamic changes in protein expression in an adult stem cell lineage. Berry CW, et al. Genes Dev, 2022 Aug 1. PMID 36175033, Free PMC Article
    5. Polymorphism and Divergence of Novel Gene Expression Patterns in Drosophila melanogaster. Cridland JM, et al. Genetics, 2020 Sep. PMID 32737121, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kumgang
    Names
    CG5204-PA
    kmg-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13160527..13163153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135760.1 → NP_609604.1  kumgang [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK36
      Related
      FBpp0080014, FBtr0080433
      Conserved Domains (1) summary
      sd00019
      Location:540 → 560
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK36 Q9VK36

    Gene LinkOut

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