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    CG13551 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13551provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040660
    Locus tag
    Dmel_CG13551
    See related
    AllianceGenome:FB:FBgn0040660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATPIF1; BcDNA:RE33866; Dmel\CG13551; IF1; SK[[66]]
    Summary
    Predicted to enable ATPase binding activity; ATPase inhibitor activity; and mitochondrial proton-transporting ATP synthase complex binding activity. Involved in defense response to Gram-positive bacterium. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic anal pad; embryonic large intestine; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13551 in Genome Data Viewer
    Location:
    59D9-59D9; 2-102 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23377866..23383424, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19265389..19270947, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Methenyltetrahydrofolate synthetase Neighboring gene virilizer Neighboring gene Interacts with the C terminus of ELL 1 Neighboring gene Golgin-245 Neighboring gene yellow-d Neighboring gene yellow-d2 Neighboring gene long non-coding RNA:CR44784 Neighboring gene uncharacterized protein Neighboring gene reduction of Rh1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis. Lu J, et al. Peptides, 2010 Jan. PMID 19799950
    2. SK66-his, a novel glycine-rich peptide derived from Drosophila with antibacterial activity. Feng Z, et al. Biosci Biotechnol Biochem, 2009 Mar 23. PMID 19270403
    3. Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila. Kandul NP, et al. Nat Commun, 2016 Nov 14. PMID 27841259, Free PMC Article
    4. Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline. Lieber T, et al. Nature, 2019 Jun. PMID 31092924, Free PMC Article
    5. Hundreds of putatively functional small open reading frames in Drosophila. Ladoukakis E, et al. Genome Biol, 2011 Nov 25. PMID 22118156, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mitochondrial proton-transporting ATP synthase complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of ATP-dependent activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13551-PA
    CG13551-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23377866..23383424 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144045.2 → NP_652302.1  uncharacterized protein Dmel_CG13551, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8X8, Q8SYU1
      Related
      FBpp0071942
      Conserved Domains (1) summary
      pfam04568
      Location:3 → 97
      IATP; Mitochondrial ATPase inhibitor, IATP

    2. NM_166597.2 → NP_726315.1  uncharacterized protein Dmel_CG13551, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8X8, Q8SYU1
      Related
      FBpp0071943
      Conserved Domains (1) summary
      pfam04568
      Location:3 → 97
      IATP; Mitochondrial ATPase inhibitor, IATP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8X8 Q0E8X8
    Q8SYU1 Q8SYU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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