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    Ppt2 Palmitoyl-protein Thioesterase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppt2provided by FlyBase
    Official Full Name
    Palmitoyl-protein Thioesterase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032358
    Locus tag
    Dmel_CG4851
    See related
    AllianceGenome:FB:FBgn0032358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4851; Dmel\CG4851; PPT-2
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Located in lysosome. Is expressed in adult heart; larval brain; larval central nervous system; and organism. Orthologous to human PPT2 (palmitoyl-protein thioesterase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ppt2 in Genome Data Viewer
    Location:
    32E2-32E2; 2-44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11280298..11281920)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11280298..11281920)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene CENP-ana Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44182 Neighboring gene meiotic recombination 11 Neighboring gene Osiris 21 Neighboring gene long non-coding RNA:CR43409

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. Yucel JK, et al. J Cell Biol, 2000 Jul 10. PMID 10893249, Free PMC Article
    2. Characterization of Drosophila palmitoyl-protein thioesterase 1. Glaser RL, et al. Gene, 2003 Jul 17. PMID 12909364
    3. The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Ciapponi L, et al. Curr Biol, 2004 Aug 10. PMID 15296753
    4. Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration. Lee J, et al. PLoS Genet, 2013 Jun. PMID 23754968, Free PMC Article
    5. The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases. Bannan BA, et al. Fly (Austin), 2008 Jul-Aug. PMID 18719403, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. major lysosomal thioesterase; Ppt2 expression cannot rescue neural inclusion phenotypes associated with loss of Ppt1
      Title: The Drosophila protein palmitoylome: characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Palmitoyl-protein thioesterase 2
    Names
    CG4851-PA
    Ppt2-PA
    NP_609500.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11280298..11281920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135656.3 → NP_609500.1  Palmitoyl-protein thioesterase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609500.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SL2, Q9VKH6
      Related
      FBpp0079801
      Conserved Domains (1) summary
      cl21494
      Location:25 → 262
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKH6.1 Q9VKH6

    Gene LinkOut

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