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    Lip1 Lipase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lip1provided by FlyBase
    Official Full Name
    Lipase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0023496
    Locus tag
    Dmel_CG7279
    See related
    AllianceGenome:FB:FBgn0023496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7279; dLip1; Dmel\CG7279; Dmlip1; Lip; lip1; LIP1Dm
    Summary
    Predicted to enable triacylglycerol lipase activity. Involved in digestion. Is expressed in several structures, including embryonic/larval posterior spiracle; eye disc posterior to the morphogenetic furrow; gut section; larval muscle system; and primary tracheal branch. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lip1 in Genome Data Viewer
    Location:
    32A4-32A4; 2-43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10699408..10701544, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10699408..10701544, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44181 Neighboring gene uncharacterized protein Neighboring gene Lipase 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44407

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster lipase homologs: a gene family with tissue and developmental specific expression. Pistillo D, et al. J Mol Biol, 1998 Mar 13. PMID 9566193
    2. dFOXO regulates transcription of a Drosophila acid lipase. Vihervaara T, et al. J Mol Biol, 2008 Mar 7. PMID 18234213
    3. Female sterile mutations and egg chamber development in Drosophila melanogaster. Gigliotti S, et al. Int J Dev Biol, 2000. PMID 11061421
    4. Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1. Goodliffe JM, et al. BMC Mol Biol, 2007 May 22. PMID 17519021, Free PMC Article
    5. Immunity regulatory DNAs share common organizational features in Drosophila. Senger K, et al. Mol Cell, 2004 Jan 16. PMID 14731391

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in digestion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipase 1
    Names
    CG7279-PA
    CG7279-PB
    Lip1-PA
    Lip1-PB
    Lipase1
    NP_001285811.1
    NP_523540.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10699408..10701544 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078816.4 → NP_523540.1  lipase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523540.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46107, Q9VKR6
      UniProtKB/TrEMBL
      X2JDS0
      Related
      FBpp0079713
      Conserved Domains (2) summary
      pfam00561
      Location:103 → 399
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:71 → 122
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

    2. NM_001298882.1 → NP_001285811.1  lipase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285811.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46107, Q9VKR6
      UniProtKB/TrEMBL
      X2JDS0
      Conserved Domains (2) summary
      pfam00561
      Location:103 → 399
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:71 → 122
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46107.2 O46107
    X2JDS0 X2JDS0

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