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    EMC6 ER membrane protein complex subunit 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EMC6provided by FlyBase
    Official Full Name
    ER membrane protein complex subunit 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0039259
    Locus tag
    Dmel_CG11781
    See related
    AllianceGenome:FB:FBgn0039259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE35789; CG11781; Dmel\CG11781; emc6
    Summary
    Contributes to membrane insertase activity. Involved in tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of EMC complex. Is expressed in adult heart and organism. Orthologous to human EMC6 (ER membrane protein complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See EMC6 in Genome Data Viewer
    Location:
    96B16-96B16; 3-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25024473..25025017, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20850195..20850739, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mahogany Neighboring gene tenectin Neighboring gene beta-4-galactosyltransferase 7 Neighboring gene Hormone receptor-like in 96 Neighboring gene Smg6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An EMC-Hpo-Yki axis maintains intestinal homeostasis under physiological and pathological conditions. Shi L, et al. Development, 2023 Dec 15. PMID 38031990
    2. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article
    3. Application of Fluorescent Proteins for Functional Dissection of the Drosophila Visual System. Smylla TK, et al. Int J Mol Sci, 2021 Aug 19. PMID 34445636, Free PMC Article
    4. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
    5. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to membrane insertase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 6
    Names
    CG11781-PA
    EMC6-PA
    endoplasmic reticulum membrane protein complex 6
    subunit 6 of EMC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25024473..25025017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143063.2 → NP_651320.1  ER membrane protein complex subunit 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651320.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS26, Q9VBZ8
      Related
      FBpp0084172
      Conserved Domains (1) summary
      pfam07019
      Location:28 → 104
      Rab5ip; Rab5-interacting protein (Rab5ip)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS26 Q8MS26
    Q9VBZ8 Q9VBZ8

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