U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Zaf1 ZAD and Architectural Function 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41394, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Zaf1provided by FlyBase
    Official Full Name
    ZAD and Architectural Function 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037921
    Locus tag
    Dmel_CG6808
    See related
    AllianceGenome:FB:FBgn0037921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31372; CG6808; Dmel\CG6808; ZAF1
    Summary
    Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Zaf1 in Genome Data Viewer
    Location:
    86E13-86E13; 3-51 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11621466..11625644, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7447188..7451366, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jupiter Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Removal of extra sequences with I-SceI in combination with CRISPR/Cas9 technique for precise gene editing in Drosophila. Zolotarev N, et al. Biotechniques, 2019 Apr. PMID 30987444
    2. Mechanisms of enhancer-promoter communication and chromosomal architecture in mammals and Drosophila. Kyrchanova OV, et al. Front Genet, 2022. PMID 36531247, Free PMC Article
    3. Small Drosophila zinc finger C2H2 protein with an N-terminal zinc finger-associated domain demonstrates the architecture functions. Maksimenko O, et al. Biochim Biophys Acta Gene Regul Mech, 2020 Jan. PMID 31706027
    4. CTCF As an Example of DNA-Binding Transcription Factors Containing Clusters of C2H2-Type Zinc Fingers. Maksimenko OG, et al. Acta Naturae, 2021 Jan-Mar. PMID 33959385, Free PMC Article
    5. Jupiter, a new Drosophila protein associated with microtubules. Karpova N, et al. Cell Motil Cytoskeleton, 2006 May. PMID 16518797

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ZAD and architectural function 1
    Names
    CG6808-PA
    CG6808-PB
    Zaf1-PA
    Zaf1-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11621466..11625644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169411.2 → NP_731602.1  ZAD and architectural function 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZ91, Q8MRF5
      Related
      FBpp0081927, FBtr0082451
      Conserved Domains (4) summary
      smart00868
      Location:9 → 79
      zf-AD; Zinc-finger associated domain (zf-AD)
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:255 → 277
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:269 → 293
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001260126.1 → NP_001247055.1  ZAD and architectural function 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZ91, Q8MRF5
      Conserved Domains (4) summary
      smart00868
      Location:9 → 79
      zf-AD; Zinc-finger associated domain (zf-AD)
      sd00017
      Location:257 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:255 → 277
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:269 → 293
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YZ91 Q7YZ91
    Q8MRF5 Q8MRF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous