Tnpo-SR Transportin-Serine/Arginine rich [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tnpo-SRprovided by FlyBase
Official Full Name: Transportin-Serine/Arginine richprovided by FlyBase
Primary source: FLYBASE:FBgn0031456
Locus tag: Dmel_CG2848
See related: AllianceGenome:FB:FBgn0031456
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey294; CG2848; Dmel\CG2848; dTRN-SR; TNPO3; Trn-SR
Summary: Predicted to enable small GTPase binding activity. Involved in protein import into nucleus and regulation of mRNA splicing, via spliceosome. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2759924..2763889)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2759924..2763889)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

beta-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila.
Title: β-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila.
Transportin-serine/arginine-rich (Tnpo-SR) proteins are necessary for proper lipid storage in the Drosophila fat body.
Title: Transportin-serine/arginine-rich (Tnpo-SR) proteins are necessary for proper lipid storage in the Drosophila fat body.
Results imply that the mechanism by which SR proteins are imported to the nucleus is conserved between Drosophila and humans and involves the nuclear import receptor transportin-SR.
Title: A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: CG2848-PA; CG2848-PB; Tnpo-SR-PA; Tnpo-SR-PB; Transportin-serine/arginine rich; transportin

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The following sections contain reference sequences that belong to a specific genome build. Explain