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    Mkk4 MAP kinase kinase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mkk4provided by FlyBase
    Official Full Name
    MAP kinase kinase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0024326
    Locus tag
    Dmel_CG9738
    See related
    AllianceGenome:FB:FBgn0024326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    142758_at; CG9738; CT27508; D-MKK4; Dmel\CG9738; dMkk4; dMKK4; DMKK4; JNKK2; MAPKK4; mkk4; MKK4; Mpk4; P-MKK4; SEK1/MKK4
    Summary
    Predicted to enable JUN kinase kinase activity. Involved in several processes, including JNK cascade; regulation of adult chitin-containing cuticle pigmentation; and tumor necrosis factor-mediated signaling pathway. Located in axon. Is expressed in several structures, including adult head; adult mushroom body; embryonic/larval midgut primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mkk4 in Genome Data Viewer
    Location:
    85A5-85A5; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8646172..8650796, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4471894..4476518, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Tyrosine-GTA 1-5 Neighboring gene Cytochrome P450 313b1 Neighboring gene SRA stem-loop interacting RNA binding protein 2 Neighboring gene Dihydroorotate dehydrogenase Neighboring gene Sys1 golgi trafficking protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster. Srivastava A, et al. FEBS Open Bio, 2015. PMID 25737837, Free PMC Article
    2. The pink gene encodes the Drosophila orthologue of the human Hermansky-Pudlak syndrome 5 (HPS5) gene. Syrzycka M, et al. Genome, 2007 Jun. PMID 17632576
    3. Structure learning in Nested Effects Models. Tresch A, et al. Stat Appl Genet Mol Biol, 2008. PMID 18312214
    4. Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli. Zhuang ZH, et al. Cell Signal, 2006 Apr. PMID 16014325
    5. Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. Rallis A, et al. Dev Biol, 2010 Mar 1. PMID 20035736, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in Drosophila both MAPKKs, Hep/Mkk7 and Mkk4, are required to induce JNK upon TNF or pro-inflammatory stimulation
      Title: A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of adult chitin-containing cuticle pigmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP kinase kinase 4
    Names
    CG9738-PA
    CG9738-PB
    CG9738-PC
    JNK kinase 2
    MAPK kinase 4
    Map kinase kinase 4
    Mkk4-PA
    Mkk4-PB
    Mkk4-PC
    drosophila MAP kinase kinase 4
    NP_001163551.1
    NP_001262375.1
    NP_477353.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8646172..8650796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275446.1 → NP_001262375.1  MAP kinase kinase 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262375.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61444, O61445, Q7KPK6
      Conserved Domains (2) summary
      smart00220
      Location:123 → 387
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06616
      Location:115 → 405
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

    2. NM_058005.5 → NP_477353.1  MAP kinase kinase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61444, O61445, Q7KPK6
      Related
      FBpp0081378
      Conserved Domains (2) summary
      smart00220
      Location:123 → 387
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06616
      Location:115 → 405
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

    3. NM_001170080.2 → NP_001163551.1  MAP kinase kinase 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61444, O61445, Q7KPK6
      Conserved Domains (2) summary
      smart00220
      Location:123 → 387
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06616
      Location:115 → 405
      PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61444 O61444
    Q7KPK6 Q7KPK6
    Q7KPX5 Q7KPX5

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