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    Ice1 Interacts with the C terminus of ELL 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ice1provided by FlyBase
    Official Full Name
    Interacts with the C terminus of ELL 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034853
    Locus tag
    Dmel_CG13550
    See related
    AllianceGenome:FB:FBgn0034853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13550; dICE1; Dmel\CG13550; ICE1
    Summary
    Enables chromatin binding activity. Involved in snRNA transcription by RNA polymerase II. Located in euchromatin. Part of super elongation complex. Is expressed in larval muscle system; organism; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ice1 in Genome Data Viewer
    Location:
    59D9-59D9; 2-102 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23366866..23371459)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19254389..19258982)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44168 Neighboring gene uncharacterized protein Neighboring gene Methenyltetrahydrofolate synthetase Neighboring gene virilizer Neighboring gene Golgin-245 Neighboring gene uncharacterized protein Neighboring gene yellow-d Neighboring gene yellow-d2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Chung CY, et al. Nat Commun, 2018 Oct 23. PMID 30353006, Free PMC Article
    2. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Hu D, et al. Mol Cell, 2013 Aug 22. PMID 23932780, Free PMC Article
    3. Epigenetic Regulation of ALS and CMT: A Lesson from Drosophila Models. Yamaguchi M, et al. Int J Mol Sci, 2021 Jan 6. PMID 33419039, Free PMC Article
    4. Combinatorial modeling of chromatin features quantitatively predicts DNA replication timing in Drosophila. Comoglio F, et al. PLoS Comput Biol, 2014 Jan. PMID 24465194, Free PMC Article
    5. The little elongation complex regulates small nuclear RNA transcription. Smith ER, et al. Mol Cell, 2011 Dec 23. PMID 22195968, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in snRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in euchromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of super elongation complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription elongation factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_611786.1
    • interacts with the C terminus of ELL 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23366866..23371459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137942.2 → NP_611786.1  uncharacterized protein Dmel_CG13550 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611786.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRC0, Q9W1R4
      Related
      FBpp0071919
      Conserved Domains (1) summary
      COG4372
      Location:25 → 129
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1R4.2 Q9W1R4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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