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    CrebB Cyclic-AMP response element binding protein B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CrebBprovided by FlyBase
    Official Full Name
    Cyclic-AMP response element binding protein Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265784
    Locus tag
    Dmel_CG6103
    See related
    AllianceGenome:FB:FBgn0265784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6103; CRE-BP; Creb; CREB; Creb B 17A; Creb-B; CREB-b; CREB-B; Creb17A; creb2; Creb2; CREB2; Creb2-b; CREB2-b; Creb2.b; CREB2a; Creb2b; CREB2b; crebB; CrebB-17A; CrebB-17B; CrebB17-A; dCbz; dCREB; dCREB-2; dCREB-2a; dCREB-B; dCreb2; dCREB2; dCREB2-a; dcreb2-b; dCreb2-b; dCREB2-b; dCREB2a; dCreb2b; dCREB2b; dCrebB2; DM9; Dmel\CG6103; FBgn0014467; l(1)17Af; S162
    Summary
    Enables sequence-specific DNA binding activity. Involved in several processes, including memory; positive regulation of feeding behavior; and thermosensory behavior. Located in nucleus. Is expressed in adult head and organism. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human ATF1 (activating transcription factor 1); CREB1 (cAMP responsive element binding protein 1); and CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CrebB in Genome Data Viewer
    Location:
    17A7-17A8; 1-60 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18366357..18377864)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18260390..18271897)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene kairos Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43686 Neighboring gene porcupine Neighboring gene uncharacterized protein Neighboring gene Coat Protein (coatomer) beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gut microbiota metabolite tyramine ameliorates high-fat diet-induced insulin resistance via increased Ca(2+) signaling. Ma P, et al. EMBO J, 2024 Aug. PMID 38965418, Free PMC Article
    2. dCREB2-mediated enhancement of memory formation. Tubon TC Jr, et al. J Neurosci, 2013 Apr 24. PMID 23616553, Free PMC Article
    3. Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila. Lee WP, et al. PLoS Genet, 2020 Aug. PMID 32780743, Free PMC Article
    4. Time of day influences memory formation and dCREB2 proteins in Drosophila. Fropf R, et al. Front Syst Neurosci, 2014. PMID 24744705, Free PMC Article
    5. A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. Yin JC, et al. Mol Cell Biol, 1995 Sep. PMID 7651429, Free PMC Article

    See all (239) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.
      Title: CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.
    2. Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila.
      Title: Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila.
    3. pharmaceutical inhibition of CDK5 prevents glioma stem cell self-renewal in vitro and in xenografted tumors, at least partially by suppressing CREB1 activation independently of PKA/cAMP.
      Title: CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells.
    4. c-Fos/CREB cycling defines long-term memories (LTM) engram cells required for LTM.
      Title: Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling.
    5. Data demonstrate that CrebB is a rate-limiting substrate of the genetic NMD pathway important for the behavioral output of circadian clocks in Drosophila.
      Title: Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.
    6. The authors show that PKA phosphorylates Meng Po and that both proteins synergize in a feedforward loop to control CREBB levels and long-term memory.
      Title: A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.
    7. Mushroom Body alpha/beta and alpha'/beta' neurons as well as MBON alpha3, but not in dopaminergic neurons require CrebB for long term memory.
      Title: Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit.
    8. Early-onset sleep defects in mutated HTT Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
      Title: Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
    9. changes suggest that dCREB2 functions in both the ellipsoid body and the mushroom body for long term memory formation, and that this activity contributes to the process of systems consolidation.
      Title: Spatio-temporal in vivo recording of dCREB2 dynamics in Drosophila long-term memory processing.
    10. Our data suggest the model that Notch and PKC activities generate a cyclical accumulation of cytoplasmic hyper-PO4 CREB that is a precursor for generating the nuclear CREB isoforms.
      Title: Notch-inducible hyperphosphorylated CREB and its ultradian oscillation in long-term memory formation.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in anesthesia-resistant memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in learning or memory NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in locomotor rhythm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in long-term memory IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-term memory IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of feeding behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of circadian sleep/wake cycle, sleep TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhythmic behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclic-AMP response element binding protein B
    Names
    CG6103-PF
    CG6103-PG
    CG6103-PI
    CG6103-PJ
    CG6103-PM
    CG6103-PN
    CG6103-PO
    CG6103-PP
    CG6103-PQ
    CG6103-PR
    CREB
    CrebB-PF
    CrebB-PG
    CrebB-PI
    CrebB-PJ
    CrebB-PM
    CrebB-PN
    CrebB-PO
    CrebB-PP
    CrebB-PQ
    CrebB-PR
    Cyclic-AMP response element binding protein B at 17A
    Cyclic-AMP response element binding protein B at 17B
    activator
    blocker
    cAMP response element binding
    cAMP response element-binding protein
    cAMP response-element binding protein
    cAMP-regulated enhancer-binding protein
    cAMP-response element binding protein
    cAMP-response element-binding protein
    cyclic AMP response element binding protein
    dCREB2
    lethal(1)17Af
    protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18366357..18377864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103546.3 → NP_001097016.2  Cyclic-AMP response element binding protein B, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097016.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHW9
      Conserved Domains (2) summary
      cd14690
      Location:224 → 277
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:187 → 210
      pKID; pKID domain

    2. NM_001103547.4 → NP_001097017.1  Cyclic-AMP response element binding protein B, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097017.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHZ6
      Conserved Domains (2) summary
      cd14690
      Location:270 → 323
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:187 → 210
      pKID; pKID domain

    3. NM_001103548.4 → NP_001097018.1  Cyclic-AMP response element binding protein B, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097018.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHW9
      Conserved Domains (2) summary
      cd14690
      Location:224 → 277
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:187 → 210
      pKID; pKID domain

    4. NM_001272749.2 → NP_001259678.1  Cyclic-AMP response element binding protein B, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHW9
      Conserved Domains (2) summary
      cd14690
      Location:224 → 277
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:187 → 210
      pKID; pKID domain

    5. NM_001382186.1 → NP_001368947.1  Cyclic-AMP response element binding protein B, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd14690
      Location:139 → 192
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:56 → 79
      pKID; pKID domain

    6. NM_001347813.2 → NP_001334685.1  Cyclic-AMP response element binding protein B, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1Z1CK36

    7. NM_001272748.3 → NP_001259677.1  Cyclic-AMP response element binding protein B, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259677.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHZ6
      Conserved Domains (2) summary
      cd14690
      Location:270 → 323
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:187 → 210
      pKID; pKID domain

    8. NM_001258811.3 → NP_001245740.1  Cyclic-AMP response element binding protein B, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245740.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUU1
      Conserved Domains (1) summary
      pfam02173
      Location:191 → 220
      pKID; pKID domain

    9. NM_206781.4 → NP_996504.1  Cyclic-AMP response element binding protein B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996504.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWW0
      Conserved Domains (2) summary
      cd14690
      Location:228 → 281
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:191 → 214
      pKID; pKID domain

    10. NM_206783.4 → NP_996506.2  Cyclic-AMP response element binding protein B, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996506.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHZ6
      Conserved Domains (2) summary
      cd14690
      Location:270 → 323
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:187 → 210
      pKID; pKID domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1Z1CK36 A0A1Z1CK36
    C6SUU1 C6SUU1
    M9PHW9 M9PHW9
    M9PHZ6 M9PHZ6
    Q9VWW0.1 Q9VWW0

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