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    Usp7 Ubiquitin-specific protease 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp7provided by FlyBase
    Official Full Name
    Ubiquitin-specific protease 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0030366
    Locus tag
    Dmel_CG1490
    See related
    AllianceGenome:FB:FBgn0030366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1490; Dmel\CG1490; Q9VYQ8; Usp-7; usp7; USP7
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in negative regulation of hippo signaling; positive regulation of heterochromatin formation; and positive regulation of smoothened signaling pathway. Located in chromosome; cytosol; and nucleus. Part of protein-containing complex. Is expressed in several structures, including adult head; central brain primordium; embryonic brain; and imaginal disc. Orthologous to human USP7 (ubiquitin specific peptidase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp7 in Genome Data Viewer
    Location:
    11A1-11A2; 1-38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12022837..12029032, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11916870..11923065, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene LSM12 homolog a Neighboring gene Transport and Golgi organization 4 Neighboring gene Cytochrome P450 311a1 Neighboring gene Cytochrome P450 318a1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deubiquitinase USP7 regulates Drosophila aging through ubiquitination and autophagy. Cui L, et al. Aging (Albany NY), 2020 Nov 20. PMID 33221768, Free PMC Article
    2. The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance. Lake CM, et al. Proc Natl Acad Sci U S A, 2024 Sep 3. PMID 39190345, Free PMC Article
    3. H2A deubiquitinases UBP12/13 are part of the Arabidopsis polycomb group protein system. Derkacheva M, et al. Nat Plants, 2016 Aug 15. PMID 27525512
    4. Quality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models. Amaral AJ, et al. Front Genet, 2014. PMID 24634674, Free PMC Article
    5. USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway. Zhang T, et al. Proc Natl Acad Sci U S A, 2020 Nov 10. PMID 33106424, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance.
      Title: The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance.
    2. Deubiquitinase USP7 regulates Drosophila aging through ubiquitination and autophagy.
      Title: Deubiquitinase USP7 regulates Drosophila aging through ubiquitination and autophagy.
    3. Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie. Hippo pathway attenuates the binding of a ubiquitin-specific protease Usp7 to Yki, which regulates Hippo signaling through deubiquitinating Yki.
      Title: Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie.
    4. reveal a conserved mechanism by which Ci/Gli is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers
      Title: Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.
    5. Genetic and gene expression analyses suggested that GMPS/USP7 acts as a transcriptional corepressor
      Title: Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes.
    6. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
      Title: GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ubiquitin-specific protease 7
    Names
    CG1490-PB
    CG1490-PC
    Usp7-PB
    Usp7-PC
    ubiquitin-specific protease 7
    NP_001285149.1
    NP_572779.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12022837..12029032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132551.3 → NP_572779.2  Ubiquitin-specific protease 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572779.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJQ7, Q9VYQ8
      Related
      FBpp0073474
      Conserved Domains (1) summary
      COG5077
      Location:101 → 1119
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

    2. NM_001298220.1 → NP_001285149.1  Ubiquitin-specific protease 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEX7
      Conserved Domains (5) summary
      COG5077
      Location:101 → 1115
      COG5077; Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02659
      Location:239 → 549
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd03772
      Location:100 → 229
      MATH_HAUSP; Herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7) family, N-terminal MATH (TRAF-like) domain; composed of proteins similar to human HAUSP, an enzyme that specifically catalyzes the deubiquitylation of p53 and MDM2, hence ...
      pfam12436
      Location:647 → 879
      USP7_ICP0_bdg; ICP0-binding domain of Ubiquitin-specific protease 7
      pfam14533
      Location:893 → 1109
      USP7_C2; Ubiquitin-specific protease C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RD6 Q95RD6
    Q9VYQ8.1 Q9VYQ8
    X2JEX7 X2JEX7

    Gene LinkOut

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