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    fd96Ca forkhead domain 96Ca [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43010, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fd96Caprovided by FlyBase
    Official Full Name
    forkhead domain 96Caprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004897
    Locus tag
    Dmel_CG11921
    See related
    AllianceGenome:FB:FBgn0004897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11921; Dm-FoxB1; Dmel\CG11921; Dmfd4; fd4; FD4; FoxB
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Is expressed in several structures, including central brain primordium; embryonic maxillary sensory complex; ganglia; gnathal primordium; and neuroblasts. Orthologous to several human genes including FOXB2 (forkhead box B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fd96Ca in Genome Data Viewer
    Location:
    96B20-96B20; 3-86 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25082684..25084878)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20908406..20910600)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene shams Neighboring gene uncharacterized protein Neighboring gene forkhead domain 96Cb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FoxB, a new and highly conserved key factor in arthropod dorsal-ventral (DV) limb patterning. Heingård M, et al. Evodevo, 2019. PMID 31728178, Free PMC Article
    2. Developmentally regulated Drosophila gene family encoding the fork head domain. Häcker U, et al. Proc Natl Acad Sci U S A, 1992 Sep 15. PMID 1356269, Free PMC Article
    3. Five years on the wings of fork head. Kaufmann E, et al. Mech Dev, 1996 Jun. PMID 8817449
    4. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Clark KL, et al. Nature, 1993 Jul 29. PMID 8332212
    5. Bipartite recognition of DNA by TCF/Pangolin is remarkably flexible and contributes to transcriptional responsiveness and tissue specificity of wingless signaling. Archbold HC, et al. PLoS Genet, 2014 Sep. PMID 25188465, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    forkhead domain 96Ca
    Names
    CG11921-PA
    CG11921-PB
    fd96Ca-PA
    fd96Ca-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25082684..25084878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300587.1 → NP_001287516.1  forkhead domain 96Ca, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287516.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32028, Q058R6, Q9VBY1
      UniProtKB/TrEMBL
      A0A0B4LHW8
      Conserved Domains (1) summary
      smart00339
      Location:13 → 101
      FH; FORKHEAD

    2. NM_079771.2 → NP_524495.1  forkhead domain 96Ca, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524495.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32028, Q058R6, Q9VBY1
      UniProtKB/TrEMBL
      A0A0B4LHW8
      Related
      FBpp0084145
      Conserved Domains (1) summary
      smart00339
      Location:13 → 101
      FH; FORKHEAD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHW8 A0A0B4LHW8
    P32028.2 P32028

    Gene LinkOut

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