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    Rab32 Rab32 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab32provided by FlyBase
    Official Full Name
    Rab32provided by FlyBase
    Primary source
    FLYBASE:FBgn0002567
    Locus tag
    Dmel_CG8024
    See related
    AllianceGenome:FB:FBgn0002567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    24652026; 24652028; A1Z7S1; anon-WO0118547.106; beck; CG8024; Dmel\CG8024; DmRab32; DRABR1; DrabRP1; ltd; Ltd; Rab-r1; Rab-RP1; RAB-RP1; Rab-RP1/CG8024; rab32; Rab32/RP1; RAB7L; Rab7L1; RabRP1
    Summary
    Predicted to enable GTPase activity. Involved in several processes, including compound eye pigmentation; eye pigment granule organization; and ommochrome biosynthetic process. Located in autophagosome and lysosome. Is active in mitochondrial outer membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult optic lobe; brain; and photoreceptor. Used to study Parkinson's disease. Orthologous to human RAB32 (RAB32, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rab32 in Genome Data Viewer
    Location:
    45B2-45B3; 2-60 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9177864..9186342, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5065369..5073847, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Rad51 recombinase D Neighboring gene uncharacterized protein Neighboring gene Receptor mediated endocytosis 8 Neighboring gene long non-coding RNA:CR44284 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene unplugged

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epistasis in eye colors of Drosophila melanogaster. Reedy JJ, et al. J Hered, 1971 Mar-Apr. PMID 4999937
    2. Molecular and functional characterization of a unique Rab protein, RABRP1, containing the WDIAGQE sequence in a GTPase motif. Fujikawa K, et al. Zoolog Sci, 2002 Sep. PMID 12362051
    3. THE GENETICS OF ADAPTATION: THE GENETIC BASIS OF RESISTANCE TO WASP PARASITISM IN DROSOPHILA MELANOGASTER. Orr HA, et al. Evolution, 1997 Dec. PMID 28565120
    4. Developmental and genetic studies on kynurenine hydroxylase from Drosophila melanogaster. Sullivan DT, et al. Genetics, 1973 Dec. PMID 4205046, Free PMC Article
    5. Terminal synthesis of xanthommatin in Drosophila melanogaster. I. Roles of phenol oxidase and substrate availability. Phillips JP, et al. Biochem Genet, 1970 Aug. PMID 4989581

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.
      Title: Vesicular transport mediates the uptake of cytoplasmic proteins into mitochondria in Drosophila melanogaster.
    2. data suggest that RABRP1 is involved in the lysosomal vesicle transport pathway, including the biogenesis or degradation of pigment granules
      Title: Molecular and functional characterization of a unique Rab protein, RABRP1, containing the WDIAGQE sequence in a GTPase motif.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in compound eye pigmentation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eye pigment granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in melanosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ommochrome biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome HDA PubMed 
    located_in synapse HDA PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rab32
    Names
    CG8024-PB
    CG8024-PC
    CG8024-PD
    CG8024-PE
    CG8024-PH
    CG8024-PI
    CG8024-PJ
    Rab-related protein 1
    Rab32-PB
    Rab32-PC
    Rab32-PD
    Rab32-PE
    Rab32-PH
    Rab32-PI
    Rab32-PJ
    lightoid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9177864..9186342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165658.2 → NP_724763.1  Rab32, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7S1, Q86PD0
      Related
      FBpp0088872
      Conserved Domains (2) summary
      smart00175
      Location:20 → 188
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:20 → 222
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    2. NM_165660.2 → NP_724765.1  Rab32, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724765.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0G8
      Related
      FBpp0088871
      Conserved Domains (2) summary
      smart00175
      Location:186 → 354
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:186 → 388
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    3. NM_165659.2 → NP_724764.1  Rab32, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724764.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0G8
      Related
      FBpp0088873
      Conserved Domains (2) summary
      smart00175
      Location:186 → 354
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:186 → 388
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    4. NM_001299309.1 → NP_001286238.1  Rab32, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEY0, Q86PD0
      Conserved Domains (2) summary
      smart00175
      Location:12 → 180
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:12 → 214
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    5. NM_080370.4 → NP_525109.1  Rab32, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525109.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7S3
      Related
      FBpp0088870
      Conserved Domains (2) summary
      smart00175
      Location:484 → 652
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:484 → 686
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    6. NM_165663.3 → NP_724768.3  Rab32, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724768.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7S2
      Conserved Domains (2) summary
      smart00175
      Location:187 → 355
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:187 → 389
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    7. NM_001299308.1 → NP_001286237.1  Rab32, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEY0, Q86PD0
      Conserved Domains (2) summary
      smart00175
      Location:12 → 180
      RAB; Rab subfamily of small GTPases
      cd04107
      Location:12 → 214
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEY0 A0A0B4LEY0
    A1Z7S1 A1Z7S1
    A1Z7S2 A1Z7S2
    A1Z7S3 A1Z7S3
    Q7KY07 Q7KY07
    Q86PD0 Q86PD0
    Q8IH37 Q8IH37
    Q8T0G8 Q8T0G8

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