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    Usp1 Ubiquitin specific protease 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp1provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028476
    Locus tag
    Dmel_CG15817
    See related
    AllianceGenome:FB:FBgn0028476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD22910; CG15817; Dmel\CG15817; LD22910; Q8I077; usp1; USP1
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Is expressed in organism. Orthologous to human USP1 (ubiquitin specific peptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp1 in Genome Data Viewer
    Location:
    99A1-99A1; 3-98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29229161..29235302)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25054883..25061024)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene Bromodomain containing 8 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila. Farkas A, et al. Sci Rep, 2023 Dec 11. PMID 38081944, Free PMC Article
    2. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. Litovchenko M, et al. Sci Adv, 2021 Jan. PMID 33514540, Free PMC Article
    3. Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster. Zhang W, et al. BMC Bioinformatics, 2008 Feb 28. PMID 18307794, Free PMC Article
    4. USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. Ristic G, et al. J Biol Chem, 2016 Apr 22. PMID 26917723, Free PMC Article
    5. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen X, et al. Genetics, 2000 Dec. PMID 11102377, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin specific protease 1
    Names
    CG15817-PC
    CG15817-PD
    CG15817-PE
    Usp1-PC
    Usp1-PD
    Usp1-PE
    NP_001263061.1
    NP_651687.3
    NP_733282.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29229161..29235302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276132.1 → NP_001263061.1  ubiquitin specific protease 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I077, Q9U4F9, Q9VAM3
      Conserved Domains (1) summary
      cl02553
      Location:308 → 819
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    2. NM_143430.4 → NP_651687.3  ubiquitin specific protease 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651687.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I077, Q9U4F9, Q9VAM3
      Conserved Domains (1) summary
      cl02553
      Location:308 → 819
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    3. NM_170403.3 → NP_733282.1  ubiquitin specific protease 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733282.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I077, Q9U4F9, Q9VAM3
      Related
      FBpp0290056
      Conserved Domains (1) summary
      cl02553
      Location:308 → 819
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I077 Q8I077

    Gene LinkOut

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