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    mav maverick [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mavprovided by FlyBase
    Official Full Name
    maverickprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039914
    Locus tag
    Dmel_CG1901
    See related
    AllianceGenome:FB:FBgn0039914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1901; Dmel\CG1901; DmMav; Mav; MAV; TGF-b
    Summary
    Predicted to enable cytokine activity. Involved in several processes, including BMP signaling pathway; positive regulation of neuromuscular junction development; and regulation of imaginal disc-derived wing size. Located in synaptic cleft. Is expressed in several structures, including embryonic/larval gut; embryonic/larval midgut primordium; germ layer; germline cell; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mav in Genome Data Viewer
    Location:
    102D1-102D1; 4-0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (623219..626031, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (643845..646657, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene onecut Neighboring gene Eph receptor tyrosine kinase Neighboring gene mir-954 stem loop Neighboring gene GABA transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of maverick, a novel member of the TGF-beta superfamily in Drosophila. Nguyen M, et al. Mech Dev, 2000 Jul. PMID 10906462
    2. The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration. Varadarajan S, et al. Cell Death Differ, 2015 Aug. PMID 25656655, Free PMC Article
    3. Distinct functions of a cGMP-dependent protein kinase in nerve terminal growth and synaptic vesicle cycling. Dason JS, et al. J Cell Sci, 2019 Apr 5. PMID 30837290
    4. The Drosophila Ret gene functions in the stomatogastric nervous system with the Maverick TGFβ ligand and the Gfrl co-receptor. Myers L, et al. Development, 2018 Feb 2. PMID 29361562, Free PMC Article
    5. Discovery of supernumerary B chromosomes in Drosophila melanogaster. Bauerly E, et al. Genetics, 2014 Apr. PMID 24478336, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of imaginal disc-derived wing size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    maverick
    Names
    CG1901-PA
    DmMaverick
    mav-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      623219..626031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079887.3 → NP_524626.1  maverick [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZQ4, Q9V4E6
      Related
      FBpp0088172
      Conserved Domains (2) summary
      pfam00019
      Location:599 → 700
      TGF_beta; Transforming growth factor beta like domain
      pfam00688
      Location:442 → 506
      TGFb_propeptide; TGF-beta propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZQ4 Q8SZQ4
    Q9V4E6 Q9V4E6

    Gene LinkOut

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