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    CG10333 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35112, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10333provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032690
    Locus tag
    Dmel_CG10333
    See related
    AllianceGenome:FB:FBgn0032690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg10333; Dmel\CG10333; DmPrp28; DmRH19
    Summary
    Predicted to enable mRNA binding activity. Involved in regulation of defense response to virus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head and spermatozoon. Orthologous to human DDX23 (DEAD-box helicase 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10333 in Genome Data Viewer
    Location:
    36F7-36F7; 2-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18606832..18609550)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18606832..18609550)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 2 Neighboring gene Intraflagellar transport 46

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Splicing proofreading at 5' splice sites by ATPase Prp28p. Yang F, et al. Nucleic Acids Res, 2013 Apr. PMID 23462954, Free PMC Article
    2. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
    3. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article
    4. Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Moy RH, et al. Cell, 2014 Aug 14. PMID 25126784, Free PMC Article
    5. Evolution of intron/exon structure of DEAD helicase family genes in Arabidopsis, Caenorhabditis, and Drosophila. Boudet N, et al. Genome Res, 2001 Dec. PMID 11731501, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10333-PA
    NP_609888.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18606832..18609550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136044.3 → NP_609888.2  uncharacterized protein Dmel_CG10333 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609888.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ74
      Related
      FBpp0080622
      Conserved Domains (3) summary
      smart00487
      Location:409 → 632
      DEXDc; DEAD-like helicases superfamily
      cd00268
      Location:396 → 629
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:651 → 761
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SF2 Q95SF2
    Q9VJ74 Q9VJ74

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