upd1 unpaired 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: upd1provided by FlyBase
Official Full Name: unpaired 1provided by FlyBase
Primary source: FLYBASE:FBgn0004956
Locus tag: Dmel_CG5993
See related: AllianceGenome:FB:FBgn0004956
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5993; Dmel\CG5993; l(1)YC43; l(1)YM55; od; odsy; os; Os; OS; sis-c; sis-C; sisC; sy; unp; Unpaireds; upa; upd; Upd; UPD; Upd1; UPD1
Summary: Enables cytokine activity and extracellular matrix binding activity. Involved in several processes, including digestive tract development; epithelial cell development; and imaginal disc morphogenesis. Located in apical part of cell and extracellular space. Is expressed in several structures, including cuboidal/columnar epithelium; gut section; imaginal disc; somatic cell of ovariole; and somatic precursor cell. Used to study congenital leptin deficiency. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 17A5-17A5; 1-60 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18305354..18309291, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18199387..18203324, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

effects of upd1 overexpression on lifespan
Title: Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster.
a mechanism based on the dilution of the growth modulator Upd can explain how growth termination is controlled in the eye disc
Title: Growth control in the Drosophila eye disc by the cytokine Unpaired.
adipose- and brain-derived upd/leptin may control differing features of weight regulation through distinct neural circuits.
Title: A Leptin Analog Locally Produced in the Brain Acts via a Conserved Neural Circuit to Modulate Obesity-Linked Behaviors in Drosophila.
ROS/JNK/p38/Upd stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Title: ROS-Induced JNK and p38 Signaling Is Required for Unpaired Cytokine Activation during Drosophila Regeneration.
in the Drosophila egg chamber, two anterior cells secrete Unpaired to activate Signal transducer and activator of transcription (STAT) signalling in the epithelium.
Title: Tissue landscape alters adjacent cell fates during Drosophila egg development.
data suggest that Dally and Dlp are essential regulators for Upd distribution and JAK/STAT signaling activity in eye development
Title: Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development.
Upd and JAK/STAT signaling induce apoptosis of supernumerary polar cells (PC) to control the size of the PC organizing center and thereby produce appropriate levels of Upd.
Title: JAK/STAT autocontrol of ligand-producing cell number through apoptosis.
findings demonstrate that the glypicans dally and dlp regulate formation of the follicular gradient of the Upd morphogen, Upd
Title: Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen.
Study isolated miR-279 as an effecter of clock-controlled behavioral output, and identified Upd, the ortholog of the JAK/STAT ligand, as the circadian-relevant target of this miRNA.
Title: Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit.
not only is Upd specifically required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required
Title: Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IGI Inferred from Genetic Interaction more info	PubMed
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apical constriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blastoderm segmentation	TAS Traceable Author Statement more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in determination of digestive tract left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IEA Inferred from Electronic Annotation more info
involved_in establishment of ommatidial planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mediolateral intercalation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	HMP more info	PubMed
involved_in paracrine signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in primary sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex determination, establishment of X:A ratio	NAS Non-traceable Author Statement more info	PubMed
involved_in stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unpaired 1

Names: CG5993-PA; CG5993-PB; CG5993-PC; Unpaired/Out-stretched; outstretched; outstretched small eye; outstretched-smalleye; sisterless c; small-eye; unpaired; unpaired1; upd homolog; upd1-PA; upd1-PB; upd1-PC