U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ctl1 Choline transporter-like 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38523, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ctl1provided by FlyBase
    Official Full Name
    Choline transporter-like 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035523
    Locus tag
    Dmel_CG1311
    See related
    AllianceGenome:FB:FBgn0035523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1311; DmCTL1; Dmel\CG1311
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to several human genes including SLC44A3 (solute carrier family 44 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ctl1 in Genome Data Viewer
    Location:
    64A12-64A12; 3-10 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4277962..4281585)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4277962..4281585)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase M9.7 subunit a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shrew

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila Choline transporter non-canonically regulates pupal eclosion and NMJ integrity through a neuronal subset of mushroom body. Hamid R, et al. Dev Biol, 2019 Feb 1. PMID 30529058
    2. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Traiffort E, et al. J Neurochem, 2005 Mar. PMID 15715662
    3. Functionally Validating Evolutionary Conserved Risk Genes for Parkinson's Disease in Drosophila melanogaster. Baisgaard AE, et al. Insects, 2023 Feb 9. PMID 36835737, Free PMC Article
    4. Glial solute carrier transporters in Drosophila and mice. Featherstone DE. Glia, 2011 Sep. PMID 21732427
    5. The circadian clock interacts with metabolic physiology to influence reproductive fitness. Xu K, et al. Cell Metab, 2011 Jun 8. PMID 21641546, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Choline transporter non-canonically regulates pupal eclosion and NMJ integrity through a neuronal subset of mushroom body.
      Title: Drosophila Choline transporter non-canonically regulates pupal eclosion and NMJ integrity through a neuronal subset of mushroom body.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    choline transporter-like 1
    Names
    CG1311-PA
    CG1311-PB
    Ctl1-PA
    Ctl1-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4277962..4281585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139627.2 → NP_647884.1  choline transporter-like 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647884.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86P33, Q9VZE7
      UniProtKB/TrEMBL
      U3PXB1
      Related
      FBpp0073088
      Conserved Domains (2) summary
      pfam04515
      Location:286 → 629
      Choline_transpo; Plasma-membrane choline transporter
      pfam14800
      Location:207 → 316
      DUF4481; Domain of unknown function (DUF4481)

    2. NM_001274482.1 → NP_001261411.1  choline transporter-like 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHD2
      Conserved Domains (2) summary
      pfam04515
      Location:286 → 624
      Choline_transpo; Plasma-membrane choline transporter
      pfam14800
      Location:207 → 316
      DUF4481; Domain of unknown function (DUF4481)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHD2 M9PHD2
    Q9VZE7.1 Q9VZE7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous