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    CG16799 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37340, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG16799provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034538
    Locus tag
    Dmel_CG16799
    See related
    AllianceGenome:FB:FBgn0034538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cg16799; Dmel\CG16799
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular space. Is expressed in adult heart. Orthologous to several human genes including LYZ (lysozyme); LYZL1 (lysozyme like 1); and LYZL2 (lysozyme like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG16799 in Genome Data Viewer
    Location:
    57A9-57A9; 2-91 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20652557..20655096, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16540062..16542601, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit K Neighboring gene Threonyl-carbamoyl synthesis 1 Neighboring gene DNA methyltransferase 1 associated protein 1 Neighboring gene Leucine-rich tendon-specific protein Neighboring gene transfer RNA:Tryptophan-CCA 1-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Core Components of the Nuclear Pore Bind Distinct States of Chromatin and Contribute to Polycomb Repression. Gozalo A, et al. Mol Cell, 2020 Jan 2. PMID 31784359, Free PMC Article
    2. Characterization of the c-type lysozyme gene family in Anopheles gambiae. Li B, et al. Gene, 2005 Nov 7. PMID 16137842
    3. Protein evolution and codon usage bias on the neo-sex chromosomes of Drosophila miranda. Bachtrog D. Genetics, 2003 Nov. PMID 14668377, Free PMC Article
    4. Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2'3'-cGAMP Responses. Hédelin L, et al. Mol Biol Evol, 2024 Mar 1. PMID 38377349, Free PMC Article
    5. Expression Divergence of Chemosensory Genes between Drosophila sechellia and Its Sibling Species and Its Implications for Host Shift. Shiao MS, et al. Genome Biol Evol, 2015 Oct 1. PMID 26430061, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysozyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG16799-PA
    CG16799-PB
    NP_001286641.1
    NP_611504.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20652557..20655096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299712.1 → NP_001286641.1  uncharacterized protein Dmel_CG16799, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBX6, C0HBU0
      Conserved Domains (1) summary
      cd00119
      Location:41 → 162
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    2. NM_137660.4 → NP_611504.2  uncharacterized protein Dmel_CG16799, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611504.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBX6, C0HBU0
      Related
      FBpp0085561
      Conserved Domains (1) summary
      cd00119
      Location:41 → 162
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBX6 A1ZBX6

    Gene LinkOut

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