pnr pannier [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pnrprovided by FlyBase
Official Full Name: pannierprovided by FlyBase
Primary source: FLYBASE:FBgn0003117
Locus tag: Dmel_CG3978
See related: AllianceGenome:FB:FBgn0003117
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3978; CG3978-PA; dGATAa; dGATAa/pannier; Dmel\CG3978; GATA; GATA4; GATAa; GATAa/Pannier; l(3)89B3; Pnr; PNR; prn
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and protein heterodimerization activity. Involved in several processes, including heart development; pericardial nephrocyte differentiation; and regulation of gene expression. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in nucleus. Is expressed in several structures, including amnioserosa anlage; anterior-posterior subdivision of organism; cardiogenic mesoderm; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including adenocarcinoma (multiple); artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to several human genes including GATA5 (GATA binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89A13-89B1; 3-58 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (16026079..16041796)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11851801..11867518)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Determination of Complex Formation between Drosophila Nrf2 and GATA4 Factors at Selective Chromatin Loci Demonstrates Transcription Coactivation.
Title: Determination of Complex Formation between Drosophila Nrf2 and GATA4 Factors at Selective Chromatin Loci Demonstrates Transcription Coactivation.
Overexpression of Tinman and Pannier resulted in 20% of embryos with ectopic Hand and Sur expression. By adding MEF2 alongside Tinman and Pannier, an expansion in expression of Hand and Sur was observed.
Title: The Drosophila Transcription Factors Tinman and Pannier Activate and Collaborate with Myocyte Enhancer Factor-2 to Promote Heart Cell Fate.
A second 20E-mediated mechanism, which robustly affects only a subset of AMP genes, is uniquely controlled by BR-C, SRP and PNR.
Title: Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity.
pnr appears to be highly regulated by Dpp and Brk on both the DV and AP axes during embryo patterning.
Title: Response to the BMP gradient requires highly combinatorial inputs from multiple patterning systems in the Drosophila embryo.
Genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate.
Title: Spire, an actin nucleation factor, regulates cell division during Drosophila heart development.
This study uncovers complex transcriptional interactions between the pnr isoforms and the cofactor Ush that may be important for regulation of proneural expression and thorax patterning.
Title: Transcriptional interactions between the pannier isoforms and the cofactor U-shaped during neural development in Drosophila.
Stat and Pnr represent two essential factors controlling blood cell maturation in the developing lymph gland and exert their functions both in a cell-autonomous and non-cell-autonomous manner.
Title: JAK/STAT and the GATA factor Pannier control hemocyte maturation and differentiation in Drosophila.
Dorsal eye selector pannier (pnr) suppresses the eye fate to define dorsal margin of the Drosophila eye
Title: Dorsal eye selector pannier (pnr) suppresses the eye fate to define dorsal margin of the Drosophila eye.
Pnr is essential for early cardiac progenitor formation and also plays an important role in maintaining proper heart function.
Title: Partial loss of GATA factor Pannier impairs adult heart function in Drosophila.
show that the dual function of pnr during regulation of wingless is achieved by one isoform repressing expression of the morphogen in the dorsal-most region of the disc while the other laterally promotes activation of the notal wingless expression
Title: pannier encodes two structurally related isoforms that are differentially expressed during Drosophila development and display distinct functions during thorax patterning.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blastoderm segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaeta development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect imaginal disc fusion, thorax closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericardial nephrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigment metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antibacterial peptide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pannier

Names: CG3978-PA; CG3978-PB; CG3978-PC; CG3978-PD; pnr-PA; pnr-PB; pnr-PC; pnr-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

16026079..16041796

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275692.2 → NP_001262621.1 pannier, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262621.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T3J0, Q9VEZ8

Conserved Domains (2) summary

smart00401
Location:169 → 218

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:174 → 224

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_169697.3 → NP_732102.1 pannier, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732102.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T3J0, Q9VEZ8

Related

FBpp0082674

Conserved Domains (2) summary

smart00401
Location:169 → 218

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:174 → 224

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_001275691.2 → NP_001262620.1 pannier, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262620.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH81, Q8T3J0

Conserved Domains (2) summary

smart00401
Location:220 → 267

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:223 → 273

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
NM_057337.3 → NP_476685.1 pannier, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476685.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P52168

UniProtKB/TrEMBL

A8WHL1, Q8T3J0

Related

FBpp0082675

Conserved Domains (2) summary

smart00401
Location:223 → 270

ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]

cd00202
Location:226 → 276

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C