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    Skel Skeletor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3772559, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Skelprovided by FlyBase
    Official Full Name
    Skeletorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262717
    Locus tag
    Dmel_CG43161
    See related
    AllianceGenome:FB:FBgn0262717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2Ab3; CG14681; CG14682; CG31261; CG32922; CG33676; CG43161; Dmel\CG43161; skeletor
    Old locus tag
    Dmel_CG14681; Dmel_CG33676
    Summary
    Enables structural molecule activity. Involved in spindle assembly. Located in nucleus and polytene chromosome. Is expressed in embryonic head sensory system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Skel in Genome Data Viewer
    Location:
    86C4-86C4; 3-50 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10686943..10696270)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6512665..6521992)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene long non-coding RNA:CR44230 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pugilist Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Searching for a spindle matrix. Wells WA. J Cell Biol, 2001 Sep 17. PMID 11564751, Free PMC Article
    2. Dynamic remodeling of nuclear architecture during the cell cycle. Johansen KM. J Cell Biochem, 1996 Mar 1. PMID 8867805
    3. Remodeling of nuclear architecture during the cell cycle in Drosophila embryos. Johansen KM, et al. J Cell Biochem, 1996 Dec 1. PMID 8913878
    4. Chromator, a novel and essential chromodomain protein interacts directly with the putative spindle matrix protein skeletor. Rath U, et al. J Cell Biochem, 2004 Nov 15. PMID 15389869
    5. EAST interacts with Megator and localizes to the putative spindle matrix during mitosis in Drosophila. Qi H, et al. J Cell Biochem, 2005 Aug 15. PMID 15962301

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleus organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    skeletor
    Names
    CG43161-PB
    CG43161-PC
    CG43161-PD
    CG43161-PE
    Skel-PB
    Skel-PC
    Skel-PD
    Skel-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10686943..10696270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032002.2 → NP_001027173.2  skeletor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027173.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9GPJ1

    2. NM_001260098.1 → NP_001247027.1  skeletor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247027.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0R5, Q9GPJ1
      UniProtKB/TrEMBL
      A0A0B4K6P5
      Conserved Domains (2) summary
      smart00686
      Location:158 → 264
      DM13; Domain present in fly proteins (CG14681, CG12492, CG6217), worm H06A10.1 and Arabidopsis thaliana MBG8.9
      smart00664
      Location:286 → 447
      DoH; Possible catecholamine-binding domain present in a variety of eukaryotic proteins

    3. NM_001032000.2 → NP_001027171.1  skeletor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9EQQ8, Q7YU64, Q9VGY6, Q9VGY7
      Conserved Domains (2) summary
      smart00686
      Location:158 → 264
      DM13; Domain present in fly proteins (CG14681, CG12492, CG6217), worm H06A10.1 and Arabidopsis thaliana MBG8.9
      smart00664
      Location:286 → 447
      DoH; Possible catecholamine-binding domain present in a variety of eukaryotic proteins

    4. NM_001032001.2 → NP_001027172.1  skeletor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGY6
      Conserved Domains (1) summary
      smart00686
      Location:158 → 264
      DM13; Domain present in fly proteins (CG14681, CG12492, CG6217), worm H06A10.1 and Arabidopsis thaliana MBG8.9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6P5 A0A0B4K6P5
    Q9GPJ1.3 Q9GPJ1
    Q9VGY6.2 Q9VGY6

    Gene LinkOut

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