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    GLS Glutaminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GLSprovided by FlyBase
    Official Full Name
    Glutaminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261625
    Locus tag
    Dmel_CG42708
    See related
    AllianceGenome:FB:FBgn0261625
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG42708; CG8772; CG8872; Dmel\CG42708
    Old locus tag
    Dmel_CG8772
    Summary
    Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; ganglia; lamina anlage; midline primordium; and spermatozoon. Used to study developmental and epileptic encephalopathy 71. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to several human genes including GLS (glutaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GLS in Genome Data Viewer
    Location:
    49B12-49B12; 2-67 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12670483..12679593, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8557988..8567098, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene no extended memory Neighboring gene Nucleoporin 188kDa Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Geographical delimitation of a partial selective sweep in African Drosophila melanogaster. Frezal L, et al. Mol Ecol, 2012 Dec. PMID 23110353
    2. nemy encodes a cytochrome b561 that is required for Drosophila learning and memory. Iliadi KG, et al. Proc Natl Acad Sci U S A, 2008 Dec 16. PMID 19064935, Free PMC Article
    3. C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in Drosophila Glutamatergic Neurons. Xu W, et al. J Neurosci, 2018 Aug 29. PMID 30037833, Free PMC Article
    4. dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth. Parisi F, et al. Dev Biol, 2013 Jul 1. PMID 23608455, Free PMC Article
    5. The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia. Otto N, et al. Nat Commun, 2018 Aug 29. PMID 30158546, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutaminase
    Names
    CG42708-PA
    CG42708-PB
    CG42708-PC
    CG42708-PD
    CG42708-PE
    CG42708-PF
    CG42708-PH
    CG42708-PI
    CG42708-PJ
    CG42708-PK
    GLS-PA
    GLS-PB
    GLS-PC
    GLS-PD
    GLS-PE
    GLS-PF
    GLS-PH
    GLS-PI
    GLS-PJ
    GLS-PK
    NP_001163129.1
    NP_001163130.1
    NP_001286360.1
    NP_001286361.1
    NP_610809.3
    NP_725212.1
    NP_725213.1
    NP_725215.1
    NP_725216.1
    NP_725217.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12670483..12679593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165938.3 → NP_725212.1  glutaminase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725212.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQK6, Q8IHB6
      Related
      FBpp0292099
      Conserved Domains (4) summary
      cd00204
      Location:540 → 622
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:223 → 513
      Glutaminase; Glutaminase
      pfam13637
      Location:538 → 589
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:540 → 566
      ANK; ANK repeat [structural motif]

    2. NM_165941.2 → NP_725215.1  glutaminase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725215.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z942, Q8IHB6
      Related
      FBpp0292100
      Conserved Domains (4) summary
      cd00204
      Location:482 → 564
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:165 → 455
      Glutaminase; Glutaminase
      pfam13637
      Location:480 → 531
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:482 → 508
      ANK; ANK repeat [structural motif]

    3. NM_165942.2 → NP_725216.1  glutaminase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z943, Q8IHB6
      Related
      FBpp0292101
      Conserved Domains (4) summary
      cd00204
      Location:492 → 574
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:175 → 465
      Glutaminase; Glutaminase
      pfam13637
      Location:490 → 541
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:492 → 518
      ANK; ANK repeat [structural motif]

    4. NM_001299431.1 → NP_001286360.1  glutaminase, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF95, A4IJ68
      Conserved Domains (4) summary
      cd00204
      Location:561 → 643
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:244 → 534
      Glutaminase; Glutaminase
      pfam13637
      Location:559 → 610
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:561 → 587
      ANK; ANK repeat [structural motif]

    5. NM_165943.2 → NP_725217.1  glutaminase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z944, A4IJ68
      Related
      FBpp0292102
      Conserved Domains (4) summary
      cd00204
      Location:571 → 653
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:254 → 544
      Glutaminase; Glutaminase
      pfam13637
      Location:569 → 620
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:571 → 597
      ANK; ANK repeat [structural motif]

    6. NM_165939.3 → NP_725213.1  glutaminase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725213.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHB6, Q961I1
      Related
      FBpp0292098
      Conserved Domains (4) summary
      cd00204
      Location:550 → 632
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:233 → 523
      Glutaminase; Glutaminase
      pfam13637
      Location:548 → 599
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:550 → 576
      ANK; ANK repeat [structural motif]

    7. NM_136965.5 → NP_610809.3  glutaminase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610809.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4IJ68, Q0E9A1
      Conserved Domains (4) summary
      cd00204
      Location:505 → 587
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:188 → 478
      Glutaminase; Glutaminase
      pfam13637
      Location:503 → 554
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:505 → 531
      ANK; ANK repeat [structural motif]

    8. NM_001169658.2 → NP_001163129.1  glutaminase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163129.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RL13, Q8IHB6
      Conserved Domains (4) summary
      cd00204
      Location:540 → 622
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:223 → 513
      Glutaminase; Glutaminase
      pfam13637
      Location:538 → 589
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:540 → 566
      ANK; ANK repeat [structural motif]

    9. NM_001169659.1 → NP_001163130.1  glutaminase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163130.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH47, Q8IHB6
      Conserved Domains (4) summary
      cd00204
      Location:482 → 564
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:165 → 455
      Glutaminase; Glutaminase
      pfam13637
      Location:480 → 531
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:482 → 508
      ANK; ANK repeat [structural motif]

    10. NM_001299432.1 → NP_001286361.1  glutaminase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGA3, Q8IHB6
      Conserved Domains (4) summary
      cd00204
      Location:477 → 559
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04960
      Location:160 → 450
      Glutaminase; Glutaminase
      pfam13637
      Location:475 → 526
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:477 → 503
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF95 A0A0B4LF95
    A0A0B4LGA3 A0A0B4LGA3
    A1Z942 A1Z942
    A1Z943 A1Z943
    A1Z944 A1Z944
    E1JH47 E1JH47
    Q0E9A1 Q0E9A1
    Q1RL13 Q1RL13
    Q7JQK6 Q7JQK6
    Q8IHB6 Q8IHB6
    Q95TE6 Q95TE6
    Q961I1 Q961I1

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