fz2 frizzled 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fz2provided by FlyBase
Official Full Name: frizzled 2provided by FlyBase
Primary source: FLYBASE:FBgn0016797
Locus tag: Dmel_CG9739
See related: AllianceGenome:FB:FBgn0016797
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9739; D-fz2; D-Fz2; Dfrz2; dfz(2); DFz-2; dfz2; dFz2; Dfz2; DFz2; DFZ2; DFz2C; dfz2r; Dfz[[2]]; Dm Fz2; Dmel\CG9739; Frizzled 2; frz2; fz-2; Fz2; FZ2; Fz2R
Summary: Enables PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway; instar larval or pupal development; and neuron differentiation. Located in nucleus and plasma membrane. Part of Wnt signalosome. Colocalizes with early endosome and late endosome. Is expressed in several structures, including anterior-posterior subdivision of organism; gut section; somatic cell of testis; synaptic neuropil domain; and visceral mesoderm derivative. Orthologous to several human genes including FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 75F9-76A3; 3-45 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19140975..19235373, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19134075..19228473, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cells located outside the reach of extracellular Wg depend on the Frizzled2 receptor to maintain signaling. Frizzled2 expression is increased in the absence of Wg secretion and is required to maintain signaling and cell survival in NRT-wg wing discs.
Title: Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing.
Maturation of a central brain flight circuit in Drosophila requires Fz2 and Ca2+ signaling.
Title: Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca²⁺ signaling.
The heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse and Ankyrin 2 as a target of Go signaling required for neuromuscular junction formation
Title: Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton.
Study finds that C-terminal fragments of the Wg receptor DFz2 accumulate in nuclear foci in association with large RNA granules localizing to the space between the inner & and outer nuclear membranes; granules are found at of inner membrane invaginations, are bounded by LamC, and can be seen leaving the nucleus.
Title: Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling.
Knockdown of Tc-fz1 alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 or Tc-fz4 RNAi knockdowns.
Title: A context-dependent combination of Wnt receptors controls axis elongation and leg development in a short germ insect.
Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway.
Title: The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development.
concluded that, at synapses, Wingless signal transduction occurs through the nuclear localization of DFrizzled2-C for potential transcriptional regulation of synapse development
Title: Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2.
Frizzled2 achieves ligand capture and internalization, whereas Arrow, and perhaps downstream signalling, are essential for lysosomal targeting.
Title: Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs.
subcellular Fz localization, through the association with other membrane proteins, is a critical aspect in regulating the signaling specificity within the Wnt/Fz signaling pathways
Title: Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity.
DFz2 functions as an endocytic receptor for Wingless in the Drosophila wing
Title: Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1767 (e-PCR)
- UniSTS:3556

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c19209429-19208114 mobile_element_type = transposon:Doc{}1048

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables Wnt receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables Wnt receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Frizzled Nuclear Import pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chitin-based larval cuticle pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived wing margin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synapse organization	IPI Inferred from Physical Interaction more info	PubMed
involved_in synaptic target inhibition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Wnt signalosome	IDA Inferred from Direct Assay more info	PubMed
part_of Wnt-Frizzled-LRP5/6 complex	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with early endosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: frizzled 2

Names: CG9739-PA; CG9739-PB; CG9739-PC; CG9739-PD; CG9739-PE; CG9739-PF; CG9739-PG; CG9739-PH; D-frizzled2; DFrizzled2; Dfrizzled[[2]]; dfrizzled 2; drosophila frizzled 2; drosophila frizzled2; frizzled-2; frizzled2; fz2-PA; fz2-PB; fz2-PC; fz2-PD; fz2-PE; fz2-PF; fz2-PG; fz2-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19140975..19235373 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275109.1 → NP_001262038.1 frizzled 2, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262038.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNV7, Q494J1, Q94916, Q9VVX2, Q9VVX3

UniProtKB/TrEMBL

B7Z072

Conserved Domains (2) summary

cd07456
Location:63 → 182

CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5

pfam01534
Location:308 → 618

Frizzled; Frizzled/Smoothened family membrane region
NM_001104173.3 → NP_001097643.1 frizzled 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097643.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNV7, Q494J1, Q94916, Q9VVX2, Q9VVX3

UniProtKB/TrEMBL

B7Z072

Conserved Domains (2) summary

cd07456
Location:63 → 182

CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5

pfam01534
Location:308 → 618

Frizzled; Frizzled/Smoothened family membrane region
NM_001275107.1 → NP_001262036.1 frizzled 2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262036.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNV7, Q494J1, Q94916, Q9VVX2, Q9VVX3

UniProtKB/TrEMBL

B7Z072

Conserved Domains (2) summary

cd07456
Location:63 → 182

CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5

pfam01534
Location:308 → 618

Frizzled; Frizzled/Smoothened family membrane region
NM_001144499.3 → NP_001137971.1 frizzled 2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137971.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNV7, Q494J1, Q94916, Q9VVX2, Q9VVX3

UniProtKB/TrEMBL

B7Z072

Conserved Domains (2) summary

cd07456
Location:63 → 182

CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5

pfam01534
Location:308 → 618

Frizzled; Frizzled/Smoothened family membrane region
NM_168787.3 → NP_730389.1 frizzled 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730389.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNV7, Q494J1, Q94916, Q9VVX2, Q9VVX3

UniProtKB/TrEMBL

B7Z072

Related

FBpp0074795

Conserved Domains (2) summary

cd07456
Location:63 → 182

CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5

pfam01534
Location:308 → 618

Frizzled; Frizzled/Smoothened family membrane region
NM_001414152.1 → NP_001401042.1 frizzled 2, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A9F2H0Z3
NM_001275108.2 → NP_001262037.1 frizzled 2, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262037.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFW3

Conserved Domains (2) summary

cd07456
Location:63 → 182

CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5

pfam01534
Location:308 → 618

Frizzled; Frizzled/Smoothened family membrane region
NM_079431.2 → NP_524155.1 frizzled 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524155.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNV7, Q494J1, Q94916, Q9VVX2, Q9VVX3

UniProtKB/TrEMBL

B7Z072

Related

FBpp0074796, FBtr0075029

Conserved Domains (2) summary

cd07456
Location:63 → 182

CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5

pfam01534
Location:308 → 618

Frizzled; Frizzled/Smoothened family membrane region