orb oo18 RNA-binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: orbprovided by FlyBase
Official Full Name: oo18 RNA-binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0004882
Locus tag: Dmel_CG10868
See related: AllianceGenome:FB:FBgn0004882
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 151666_s_at; CG10868; Dmel\CG10868; fs(3)00107; oo18; Oo18; Orb; ORB; Orb1; ORB1
Summary: Enables mRNA binding activity. Involved in cytosolic mRNA polyadenylation; oogenesis; and positive regulation of oskar mRNA translation. Located in P granule and cell cortex. Part of ribonucleoprotein complex. Is expressed in several structures, including antennal lobe; cuboidal/columnar epithelium; germarium region 2a; germline cell; and gonad. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94E9-94E9; 3-78 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23260610..23280856, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19086332..19106578, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

To be or not to be: orb, the fusome and oocyte specification in Drosophila.
Title: To be or not to be: orb, the fusome and oocyte specification in Drosophila.
Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.
Title: Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles.
maintenance of oocyte identity requires continuous orb activity.
Title: The Drosophila CPEB Protein Orb Specifies Oocyte Fate by a 3'UTR-Dependent Autoregulatory Loop.
orb is required during mid-oogenesis for the translation of the posterior/germline determinant oskar mRNA and the dorsal-ventral determinant gurken mRNA. Here, we report that orb also functions upstream of these axes determinants in the polarization of the microtubule network.
Title: The CPEB translational regulator, Orb, functions together with Par proteins to polarize the Drosophila oocyte.
The juxtaposition of RNA motifs enables cooperative regulation by CPEB1 and Msi1.
Title: Dueling RNA-binding proteins promote translational activation.
Localized cytoplasmic polyadenylation of grk mRNA by Wisp and Orb is necessary to achieve appropriate Grk protein accumulation in the D/A corner of the oocyte during mid to late oogenesis.
Title: Wispy and Orb cooperate in the cytoplasmic polyadenylation of localized gurken mRNA.
autophagy is an essential pathway regulated by Orb during early oogenesis
Title: Translational Control of Autophagy by Orb in the Drosophila Germline.
Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
Title: Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
ORB protein in Drosophila mushroom body output neurons is necessary for long-term memory formation
Title: Drosophila ORB protein in two mushroom body output neurons is necessary for long-term memory formation.
Cup blocks the precocious activation of the orb autoregulatory loop
Title: Cup blocks the precocious activation of the orb autoregulatory loop.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA binding	TAS Traceable Author Statement more info	PubMed
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytosolic mRNA polyadenylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axis specification, ovarian follicular epithelium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dorsal/ventral axis specification, ovarian follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oskar mRNA translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oo18 RNA-binding protein

Names: CG10868-PA; CG10868-PB; CG10868-PC; CG10868-PD; CG10868-PE; CG10868-PF; CG10868-PG; ORB; Oo18 RNA-binding protein; oo18 RNA binding; oo18 RNA binding protein; orb-PA; orb-PB; orb-PC; orb-PD; orb-PE; orb-PF; orb-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23260610..23280856 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275941.1 → NP_001262870.1 oo18 RNA-binding protein, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262870.1

Status: REVIEWED

UniProtKB/TrEMBL

D4G7D4, Q24433, Q9VCN7

Conserved Domains (4) summary

cd12723
Location:574 → 674

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:685 → 770

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:762 → 817

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:540 → 570

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
NM_079736.3 → NP_524460.2 oo18 RNA-binding protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524460.2

Status: REVIEWED

UniProtKB/TrEMBL

D4G7D4, Q24433, Q9VCN7

Related

FBpp0083776

Conserved Domains (4) summary

cd12723
Location:574 → 674

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:685 → 770

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:762 → 817

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:540 → 570

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
NM_170062.2 → NP_732848.1 oo18 RNA-binding protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732848.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAC0, Q8IMZ3

Related

FBpp0083777

Conserved Domains (4) summary

cd12723
Location:572 → 672

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:683 → 768

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:760 → 815

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:538 → 568

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
NM_170064.2 → NP_732850.1 oo18 RNA-binding protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732850.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IHE0, Q8IMZ2

Related

FBpp0083778

Conserved Domains (4) summary

cd12723
Location:218 → 318

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:329 → 414

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:406 → 461

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:184 → 214

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
NM_170063.2 → NP_732849.2 oo18 RNA-binding protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732849.2

Status: REVIEWED

UniProtKB/TrEMBL

C7LAC0, Q8IMZ3

Conserved Domains (4) summary

cd12723
Location:572 → 672

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:683 → 768

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:760 → 815

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:538 → 568

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
NM_170065.2 → NP_732851.2 oo18 RNA-binding protein, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732851.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8IHE0, Q8IMZ2

Conserved Domains (4) summary

cd12723
Location:218 → 318

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:329 → 414

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:406 → 461

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:184 → 214

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
NM_001170228.1 → NP_001163699.1 oo18 RNA-binding protein, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163699.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IHC3, Q8IHE0

Conserved Domains (4) summary

cd12723
Location:276 → 376

RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

cd12725
Location:387 → 472

RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins

pfam16366
Location:464 → 519

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

pfam16368
Location:242 → 272

CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus