CG33090 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG33090provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0028916
Locus tag: Dmel_CG33090
See related: AllianceGenome:FB:FBgn0028916
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS01068.2; CG15287; CG31837; CG7469; Dmel\CG33090
Summary: Predicted to enable beta-glucosidase activity and glucosyltransferase activity. Predicted to be involved in bile acid metabolic process and glycoside catabolic process. Predicted to be located in membrane. Is expressed in adult head; embryonic/larval dorsal vessel; embryonic/larval mushroom body; larval central brain; and wing pouch. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 35A4-35A4; 2-50 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (14334158..14345795)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (14334158..14345795)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables beta-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-glucosidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glucosylceramidase activity	IEA Inferred from Electronic Annotation more info
enables glucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucosylceramide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycoside catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: uncharacterized protein

Names: CG33090-PB; CG33090-PC; CG33090-PD; CG33090-PE; glucosylceramidase

NP_001285926.1

EC 3.2.1.-

EC 3.2.1.21

EC 3.2.1.45

NP_001285927.1

EC 3.2.1.-

EC 3.2.1.21

EC 3.2.1.45

NP_001285928.1

EC 3.2.1.-

EC 3.2.1.21

EC 3.2.1.45

NP_788055.2

EC 3.2.1.-

EC 3.2.1.21

EC 3.2.1.45

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

14334158..14345795

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298999.1 → NP_001285928.1 uncharacterized protein Dmel_CG33090, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285928.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JAF7

Conserved Domains (2) summary

pfam04685
Location:480 → 912

DUF608; Protein of unknown function, DUF608

pfam12215
Location:132 → 420

GBA2_N; beta-Glucocerebrosidase 2 N terminal
NM_176041.2 → NP_788055.2 uncharacterized protein Dmel_CG33090, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788055.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RIG1, Q29R22, Q7KT91, Q95TX3

Related

FBpp0080197

Conserved Domains (2) summary

pfam04685
Location:505 → 937

DUF608; Protein of unknown function, DUF608

pfam12215
Location:132 → 445

GBA2_N; beta-Glucocerebrosidase 2 N terminal
NM_001298998.1 → NP_001285927.1 uncharacterized protein Dmel_CG33090, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285927.1

Status: REVIEWED

UniProtKB/TrEMBL

X2J9U5

Conserved Domains (2) summary

pfam04685
Location:503 → 935

DUF608; Protein of unknown function, DUF608

pfam12215
Location:132 → 443

GBA2_N; beta-Glucocerebrosidase 2 N terminal
NM_001298997.1 → NP_001285926.1 uncharacterized protein Dmel_CG33090, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285926.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JE45

Conserved Domains (2) summary

pfam04685
Location:356 → 788

DUF608; Protein of unknown function, DUF608

pfam12215
Location:59 → 296

GBA2_N; beta-Glucocerebrosidase 2 N terminal