cpx complexin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cpxprovided by FlyBase
Official Full Name: complexinprovided by FlyBase
Primary source: FLYBASE:FBgn0041605
Locus tag: Dmel_CG32490
See related: AllianceGenome:FB:FBgn0041605
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH27718; BcDNA:HL04936; BcDNA:RH26459; BcDNA:RH31085; CG32490; Cpx; CPX; dmCplx; DmCpx; Dmel\CG32490
Summary: Predicted to enable SNARE binding activity. Involved in chemical synaptic transmission; negative regulation of neurotransmitter secretion; and synaptic assembly at neuromuscular junction. Located in several cellular components, including neuromuscular junction; presynaptic active zone; and type I terminal bouton. Is expressed in several structures, including adult head; larval central nervous system; neuromuscular junction; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Orthologous to human CPLX1 (complexin 1) and CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 82A1-82A3; 3-47.1 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4280221..4304604)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (105943..130326)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.
Title: Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix.
Cpx protein contributes to proper neurotransmitter and neuropeptide release in response to calcium and this control is important for the normal circadian regulation of locomotor activity.
Title: NonA and CPX Link the Circadian Clockwork to Locomotor Activity in Drosophila.
The data provide evidence for a novel physiological nitrergic molecular switch involving S-nitrosylation, which reversibly suppresses farnesylation and thereby enhances the net-clamping function of cpx.
Title: Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability.
Synapses lacking complexin have elevated spontaneous release that enables reliable tracking of the spontaneous recycling pool.
Title: Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission.
Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion
Title: Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.
SNARE fusion clamp Complexin undergoes activity-dependent phosphorylation that alters the basic properties of neurotransmission in Drosophila.
Title: Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity.
the inhibitory and activating functions of Cpx are genetically separable, and can be mapped to distinct molecular mechanisms that differentially regulate the SNARE fusion machinery.
Title: Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo.
These data indicate that the C-terminus of Drosophila complexin regulates both spontaneous and evoked neurotransmitter release through separate mechanisms
Title: Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin.
These observations indicate CPX regulates both spontaneous and evoked fusion by modulating the timing and properties of synaptotagmin activation during the synaptic vesicle cycle.
Title: Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

mir-929-RA; Dmel\mir-929-RA; CR42921-RA; Dmel\CR42921-RA

mir-929-RB; Dmel\mir-929-RB; CR42921-RB; Dmel\CR42921-RB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in type I terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: complexin

Names: CG32490-PA; CG32490-PAA; CG32490-PAB; CG32490-PC; CG32490-PE; CG32490-PG; CG32490-PH; CG32490-PI; CG32490-PJ; CG32490-PK; CG32490-PL; CG32490-PM; CG32490-PO; CG32490-PP; CG32490-PS; CG32490-PU; CG32490-PV; CG32490-PW; CG32490-PX; CG32490-PY; CG32490-PZ; cpx-PA; cpx-PAA; cpx-PAB; cpx-PC; cpx-PE; cpx-PG; cpx-PH; cpx-PI; cpx-PJ; cpx-PK; cpx-PL; cpx-PM; cpx-PO; cpx-PP; cpx-PS; cpx-PU; cpx-PV; cpx-PW; cpx-PX; cpx-PY; cpx-PZ