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    CAH9 Carbonic anhydrase 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAH9provided by FlyBase
    Official Full Name
    Carbonic anhydrase 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0039486
    Locus tag
    Dmel_CG6074
    See related
    AllianceGenome:FB:FBgn0039486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    caix; CAIX; CG6074; CT19053; Dmel\CG6074
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head and embryonic/larval midgut. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA14 (carbonic anhydrase 14); CA4 (carbonic anhydrase 4); and CA6 (carbonic anhydrase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CAH9 in Genome Data Viewer
    Location:
    97E2-97E2; 3-92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27102988..27106184, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22928710..22931906, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eater Neighboring gene Juvenile hormone binding protein 11 Neighboring gene antisense RNA:CR45209 Neighboring gene genderblind Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A glial amino-acid transporter controls synapse strength and courtship in Drosophila. Grosjean Y, et al. Nat Neurosci, 2008 Jan. PMID 18066061, Free PMC Article
    2. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
    3. HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals. Bandarra D, et al. Dis Model Mech, 2015 Feb. PMID 25510503, Free PMC Article
    4. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Overend G, et al. Sci Rep, 2016 Jun 2. PMID 27250760, Free PMC Article
    5. The Impact of Microbiome and Microbiota-Derived Sodium Butyrate on Drosophila Transcriptome and Metabolome Revealed by Multi-Omics Analysis. Zhou F, et al. Metabolites, 2021 May 6. PMID 34066348, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 9
    Names
    CAH9-PA
    CG6074-PA
    caix
    carbonic anhydrase IX
    NP_651535.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27102988..27106184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143278.2 → NP_651535.1  carbonic anhydrase 9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLI8, Q9VB76
      Related
      FBpp0084503
      Conserved Domains (1) summary
      smart01057
      Location:25 → 282
      Carb_anhydrase; Eukaryotic-type carbonic anhydrase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB76 Q9VB76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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