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    Rbp4 RNA-binding protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41668, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbp4provided by FlyBase
    Official Full Name
    RNA-binding protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0010258
    Locus tag
    Dmel_CG9654
    See related
    AllianceGenome:FB:FBgn0010258
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9654; Dmel\CG9654; rbp4; rrm4; RRM4; tsr; Tsr; TSR
    Summary
    Enables mRNA 3'-UTR binding activity; single-stranded RNA binding activity; and translation repressor activity. Involved in negative regulation of translation. Located in cytosol. Part of translation repressor complex. Is expressed in male germline cell and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbp4 in Genome Data Viewer
    Location:
    87F7-87F7; 3-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13654556..13656394, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9480278..9482116, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene squid Neighboring gene rasputin Neighboring gene Heterogeneous nuclear ribonucleoprotein at 87F Neighboring gene B52

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rbp4-Gal4, a germline driver that activates in meiosis, reveals functions for VCP in spermatid development. Butsch TJ, et al. Fly (Austin), 2023 Dec. PMID 37436409, Free PMC Article
    2. Cell type-specific translational repression of Cyclin B during meiosis in males. Baker CC, et al. Development, 2015 Oct 1. PMID 26443637, Free PMC Article
    3. Translational control in spermatogenesis. Schäfer M, et al. Dev Biol, 1995 Dec. PMID 8612956
    4. Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Kim J, et al. Science, 2017 May 19. PMID 28522526, Free PMC Article
    5. A new translational repression element and unusual transcriptional control regulate expression of don juan during Drosophila spermatogenesis. Blümer N, et al. Mech Dev, 2002 Jan. PMID 11744372

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of translation repressor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding protein 4
    Names
    CG9654-PA
    Rbp4-PA
    testis specific RRM protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13654556..13656394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057587.4 → NP_476935.1  RNA-binding protein 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24024, Q9VFT3
      Related
      FBpp0082318
      Conserved Domains (2) summary
      cd12328
      Location:137 → 209
      RRM2_hnRNPA_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A subfamily
      cl17169
      Location:33 → 110
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24024 Q24024
    Q26274 Q26274
    Q8T3X1 Q8T3X1
    Q9VFT3 Q9VFT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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