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    CaMKI Calcium/calmodulin-dependent protein kinase I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CaMKIprovided by FlyBase
    Official Full Name
    Calcium/calmodulin-dependent protein kinase Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016126
    Locus tag
    Dmel_CG1495
    See related
    AllianceGenome:FB:FBgn0016126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Calcium/calmodulin-dependent protein kinase; CamK1; CaMK1; camKI; caMKI; CamKI; CAMKI; CG1495; dCKI; Dmel\CG1495
    Summary
    Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adult head and eye. Orthologous to several human genes including CAMK1D (calcium/calmodulin dependent protein kinase ID). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CaMKI in Genome Data Viewer
    Location:
    102C1-102C1; 4-0 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (445504..453947)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (466130..474573)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44024 Neighboring gene legless Neighboring gene antisense RNA:CR45126 Neighboring gene TBP-associated factor 3 Neighboring gene uncharacterized protein Neighboring gene asator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immunochemical localization of calcium/calmodulin-dependent protein kinase I. Picciotto MR, et al. Synapse, 1995 May. PMID 7624832
    2. Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism. Clapperton JA, et al. Biochemistry, 2002 Dec 17. PMID 12475216
    3. An in vivo strategy for knockdown of circular RNAs. Pamudurti NR, et al. Cell Discov, 2020. PMID 32818061, Free PMC Article
    4. Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila. Sethi S, et al. Curr Biol, 2019 Nov 18. PMID 31679932, Free PMC Article
    5. From fruitless to sex: On the generation and diversification of an innate behavior. Peng Q, et al. Genes Brain Behav, 2021 Nov. PMID 34672079

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of extensive electrostatic and hydrophobic contacts between calmodulin (CaM) and the CaM-binding domain peptide allows a detailed analysis of the structural basis of the kinase activation process.
      Title: Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 448779-449248 mobile_element_type = transposon:INE-1{}5914
    • Loc: 450697-451157 mobile_element_type = transposon:INE-1{}5918

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calcium/calmodulin-dependent protein kinase I
    Names
    CG1495-PA
    CG1495-PB
    CG1495-PG
    CG1495-PH
    CG1495-PI
    CaMKI-PA
    CaMKI-PB
    CaMKI-PG
    CaMKI-PH
    CaMKI-PI
    calmodulin-dependent kinase
    NP_524622.1
    NP_726569.1
    NP_726570.1
    NP_726571.2
    NP_726574.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      445504..453947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079883.3 → NP_524622.1  Calcium/calmodulin-dependent protein kinase I, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JMV3
      Related
      FBpp0088134
      Conserved Domains (2) summary
      smart00220
      Location:31 → 302
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14083
      Location:27 → 301
      STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I

    2. NM_166764.2 → NP_726574.1  Calcium/calmodulin-dependent protein kinase I, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726574.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KIF7, Q8IGW6
      Related
      FBpp0088132
      Conserved Domains (2) summary
      smart00220
      Location:1 → 181
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 180
      PKc_like; Protein Kinases, catalytic domain

    3. NM_166761.2 → NP_726571.2  Calcium/calmodulin-dependent protein kinase I, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726571.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V110
      Conserved Domains (2) summary
      smart00220
      Location:31 → 287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14083
      Location:27 → 286
      STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I

    4. NM_166760.2 → NP_726570.1  Calcium/calmodulin-dependent protein kinase I, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726570.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JMV3
      Related
      FBpp0088138
      Conserved Domains (2) summary
      smart00220
      Location:31 → 302
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14083
      Location:27 → 301
      STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I

    5. NM_166759.2 → NP_726569.1  Calcium/calmodulin-dependent protein kinase I, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726569.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JMV3
      Related
      FBpp0088136
      Conserved Domains (2) summary
      smart00220
      Location:31 → 302
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14083
      Location:27 → 301
      STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V110 A4V110
    Q0KIF7 Q0KIF7
    Q7JMV3 Q7JMV3
    Q86P88 Q86P88
    Q8IGW6 Q8IGW6

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