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    CG10467 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38697, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG10467provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035679
    Locus tag
    Dmel_CG10467
    See related
    AllianceGenome:FB:FBgn0035679
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10467
    Summary
    Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Located in extracellular region. Is expressed in several structures, including adult heart; anterior endoderm; anterior endoderm anlage; embryonic/larval crystal cell; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in galactosemia 4. Orthologous to human GALM (galactose mutarotase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10467 in Genome Data Viewer
    Location:
    65A6-65A6; 3-16 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6093204..6094747, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6086304..6087847, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene short spindle 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene logjam Neighboring gene Ets at 65A Neighboring gene long non-coding RNA:CR46001

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster. Garlapow ME, et al. Behav Genet, 2017 Mar. PMID 27704301, Free PMC Article
    2. The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis. Lim DH, et al. FEBS Lett, 2011 Oct 3. PMID 21889502
    3. Proteomics in Drosophila melanogaster: first 2D database of larval hemolymph proteins. Vierstraete E, et al. Biochem Biophys Res Commun, 2003 May 16. PMID 12727233
    4. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469
    5. Survival Rate and Transcriptional Response upon Infection with the Generalist Parasite Beauveria bassiana in a World-Wide Sample of Drosophila melanogaster. Paparazzo F, et al. PLoS One, 2015. PMID 26154519, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldose 1-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose 1-epimerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactose catabolic process via UDP-galactose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10467-PA
    NP_648026.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6093204..6094747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139769.2 → NP_648026.1  uncharacterized protein Dmel_CG10467 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT28, Q9VRU1
      Related
      FBpp0076771
      Conserved Domains (1) summary
      cd09019
      Location:26 → 360
      galactose_mutarotase_like; galactose mutarotase_like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MT28 Q8MT28
    Q9VRU1 Q9VRU1

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