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    Tmem18 Transmembrane protein 18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem18provided by FlyBase
    Official Full Name
    Transmembrane protein 18provided by FlyBase
    Primary source
    FLYBASE:FBgn0050051
    Locus tag
    Dmel_CG30051
    See related
    AllianceGenome:FB:FBgn0050051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-AE003822.1; CG30051; Dmel\CG30051
    Summary
    Involved in response to starvation. Predicted to be active in nuclear membrane. Used to study abdominal obesity-metabolic syndrome 1; obesity; and type 2 diabetes mellitus. Orthologous to human TMEM18 (transmembrane protein 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmem18 in Genome Data Viewer
    Location:
    49A6-49A6; 2-67 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12436120..12436990)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8323625..8324495)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Deoxyribose-phosphate aldolase Neighboring gene Nucleoporin 54kD Neighboring gene uncharacterized protein Neighboring gene Deubiquitinating apoptotic inhibitor Neighboring gene Dystrobrevin Neighboring gene uncharacterized protein Neighboring gene Lachesin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Channel nuclear pore protein 54 directs sexual differentiation and neuronal wiring of female reproductive behaviors in Drosophila. Nallasivan MP, et al. BMC Biol, 2021 Oct 20. PMID 34666772, Free PMC Article
    2. The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling. Wiemerslage L, et al. J Endocrinol, 2016 Jun. PMID 27029472
    3. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Lu Y, et al. Nat Commun, 2016 Feb 1. PMID 26833246, Free PMC Article
    4. What model organisms and interactomics can reveal about the genetics of human obesity. Williams MJ, et al. Cell Mol Life Sci, 2012 Nov. PMID 22618246, Free PMC Article
    5. From fat fruit fly to human obesity. Smith WW, et al. Physiol Behav, 2014 Sep. PMID 24508822, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 18
    Names
    CG30051-PC
    Tmem18-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12436120..12436990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165902.4 → NP_725169.3  transmembrane protein 18 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725169.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z903, Q4V5Q0
      Conserved Domains (1) summary
      pfam14770
      Location:15 → 133
      TMEM18; Transmembrane protein 18
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z903 A1Z903

    Gene LinkOut

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