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    alpha-Est9 alpha-Esterase-9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40897, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Est9provided by FlyBase
    Official Full Name
    alpha-Esterase-9provided by FlyBase
    Primary source
    FLYBASE:FBgn0015577
    Locus tag
    Dmel_CG1128
    See related
    AllianceGenome:FB:FBgn0015577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aE9; alphaE9; CG1128; DmalphaE9; Dmel\CG1128; Dm_3R:18691; Est9; J
    Summary
    Predicted to enable carboxylesterase activity. Is expressed in organism. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Est9 in Genome Data Viewer
    Location:
    84D9-84D9; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7493921..7505098, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3319643..3330820, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Valine-CAC 2-4 Neighboring gene alpha-Esterase-10 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial morphology and cristae structure 1 Neighboring gene alpha-Esterase-8 Neighboring gene Ubiquitin conjugating enzyme 84D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cluster of esterase genes on chromosome 3R of Drosophila melanogaster includes homologues of esterase genes conferring insecticide resistance in Lucilia cuprina. Spackman ME, et al. Biochem Genet, 1994 Feb. PMID 8031294
    2. Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family. Oakeshott JG, et al. Bioessays, 1999 Dec. PMID 10580988
    3. Molecular cloning of an alpha-esterase gene cluster on chromosome 3r of Drosophila melanogaster. Russell RJ, et al. Insect Biochem Mol Biol, 1996 Mar. PMID 8900595
    4. Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Campbell PM, et al. Insect Mol Biol, 2003 Oct. PMID 12974951
    5. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. Robin C, et al. J Mol Evol, 1996 Sep. PMID 8703090

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables cholinesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  

    General protein information

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    Preferred Names
    alpha-Esterase-9
    Names
    CG1128-PC
    CG1128-PD
    alpha-Est9-PC
    alpha-Est9-PD
    fragment J
    NP_524258.2
    NP_731165.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7493921..7505098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169187.3 → NP_731165.2  alpha-Esterase-9, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731165.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24203, Q9VIB1
      Conserved Domains (2) summary
      COG0657
      Location:115 → 237
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:33 → 555
      COesterase; Carboxylesterase family

    2. NM_079534.3 → NP_524258.2  alpha-Esterase-9, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524258.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RKR1, Q9VIB0
      Conserved Domains (2) summary
      COG0657
      Location:115 → 219
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:33 → 537
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24203 Q24203
    Q9VIB0 Q9VIB0
    Q9VIB1 Q9VIB1

    Gene LinkOut

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