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    Oatp58Da Organic anion transporting polypeptide 58Da [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37543, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oatp58Daprovided by FlyBase
    Official Full Name
    Organic anion transporting polypeptide 58Daprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050277
    Locus tag
    Dmel_CG30277
    See related
    AllianceGenome:FB:FBgn0050277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30277; CG3387; Dmel\CG30277; oatp 58Da
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder; gastrointestinal stromal tumor; and primary hypertrophic osteoarthropathy. Orthologous to several human genes including SLCO1A2 (solute carrier organic anion transporter family member 1A2); SLCO1B1 (solute carrier organic anion transporter family member 1B1); and SLCO1B3 (solute carrier organic anion transporter family member 1B3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oatp58Da in Genome Data Viewer
    Location:
    58D2-58D2; 2-99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22218456..22220905, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18105961..18108410, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ariadne 2 Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 58Db Neighboring gene Organic anion transporting polypeptide 58Dc

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Essential functions of mosquito ecdysone importers in development and reproduction. Hun LV, et al. Proc Natl Acad Sci U S A, 2022 Jun 21. PMID 35696563, Free PMC Article
    2. Resolution of the insect ouabain paradox. Torrie LS, et al. Proc Natl Acad Sci U S A, 2004 Sep 14. PMID 15347816, Free PMC Article
    3. An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in Drosophila. Santabárbara-Ruiz P, et al. Dev Cell, 2021 Oct 11. PMID 34610327
    4. Sex- and segment-specific modulation of gene expression profiles in Drosophila. Barmina O, et al. Dev Biol, 2005 Dec 15. PMID 16269142
    5. Genome-Wide Association Analysis of Anoxia Tolerance in Drosophila melanogaster. Campbell JB, et al. G3 (Bethesda), 2019 Sep 4. PMID 31311780, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    organic anion transporting polypeptide 58Da
    Names
    CG30277-PA
    Oatp58Da-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22218456..22220905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137813.5 → NP_611657.2  organic anion transporting polypeptide 58Da [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611657.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4IJ67, Q9W271
      Conserved Domains (3) summary
      cd06174
      Location:69 → 425
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:462 → 514
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:67 → 626
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W271 Q9W271

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