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    NimC1 Nimrod C1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NimC1provided by FlyBase
    Official Full Name
    Nimrod C1provided by FlyBase
    Primary source
    FLYBASE:FBgn0259896
    Locus tag
    Dmel_CG8942
    See related
    AllianceGenome:FB:FBgn0259896
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00180.10; CG8942; CT25688; Dmel\CG8942; Nim; NimC; nimC1; nimrod; nimrod C1; P1
    Summary
    Involved in defense response to bacterium and phagocytosis. Located in plasma membrane. Is expressed in adult head; cortical zone of lymph gland primary lobe; embryonic/larval lymph gland; embryonic/larval plasmatocyte; and hemocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NimC1 in Genome Data Viewer
    Location:
    34E5-34E5; 2-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13973158..13976769, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13973158..13976769, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Nimrod B4 Neighboring gene Nimrod B5 Neighboring gene Hemese Neighboring gene Cytochrome P450 28a5 Neighboring gene Nimrod C2 Neighboring gene rickets

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Widely Used Mutants of eiger, Encoding the Drosophila Tumor Necrosis Factor, Carry Additional Mutations in the NimrodC1 Phagocytosis Receptor. Kodra A, et al. G3 (Bethesda), 2020 Dec 3. PMID 33127847, Free PMC Article
    2. Edin Expression in the Fat Body Is Required in the Defense Against Parasitic Wasps in Drosophila melanogaster. Vanha-Aho LM, et al. PLoS Pathog, 2015 May. PMID 25965263, Free PMC Article
    3. Methods and tools for spatial mapping of single-cell RNAseq clusters in Drosophila. Mohr SE, et al. Genetics, 2021 Apr 15. PMID 33713129, Free PMC Article
    4. Variation of NimC1 expression in Drosophila stocks and transgenic strains. Honti V, et al. Fly (Austin), 2013 Oct-Dec. PMID 23899817, Free PMC Article
    5. Drosophila melanogaster as a Model System to Assess the Effect of Epstein-Barr Virus DNA on Inflammatory Gut Diseases. Madi JR, et al. Front Immunol, 2021. PMID 33828545, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nimrod C1
    Names
    CG8942-PA
    CG8942-PB
    CG8942-PC
    NimC1-PA
    NimC1-PB
    NimC1-PC
    NimrodC1
    nimrod

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13973158..13976769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298992.1 → NP_001285921.1  nimrod C1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8G7, M9PBB4
      Conserved Domains (1) summary
      pfam09402
      Location:244 → 281
      MSC; Man1-Src1p-C-terminal domain

    2. NM_135849.4 → NP_609693.1  nimrod C1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8G7, Q9NKD8, Q9VJU5
      Related
      FBpp0080188
      Conserved Domains (2) summary
      pfam07546
      Location:25 → 89
      EMI; EMI domain
      pfam09402
      Location:242 → 279
      MSC; Man1-Src1p-C-terminal domain

    3. NM_001273524.1 → NP_001260453.1  nimrod C1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V8G7, M9PBB4
      Conserved Domains (1) summary
      pfam09402
      Location:244 → 281
      MSC; Man1-Src1p-C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBB4 M9PBB4
    Q8MS81 Q8MS81
    Q9VJU5 Q9VJU5

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