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    Axs Abnormal X segregation [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Axsprovided by FlyBase
    Official Full Name
    Abnormal X segregationprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000152
    Locus tag
    Dmel_CG9703
    See related
    AllianceGenome:FB:FBgn0000152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    axs; CG9703; Dmel\CG9703
    Summary
    Predicted to enable chloride channel activity. Involved in distributive segregation; female meiosis chromosome segregation; and meiotic spindle organization. Located in several cellular components, including endoplasmic reticulum; nuclear outer membrane; and spindle. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 10. Orthologous to human ANO10 (anoctamin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Axs in Genome Data Viewer
    Location:
    15A1-15A1; 1-55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16680089..16683895, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16574122..16577928, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene singles bar Neighboring gene Septin 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic analysis of distributive segregation in Drosophila melanogaster. I. Isolation and characterization of Aberrant X segregation (Axs), a mutation defective in chromosome partner choice. Zitron AE, et al. Genetics, 1989 Aug. PMID 2503421, Free PMC Article
    2. The spindle-associated transmembrane protein Axs identifies a new family of transmembrane proteins in eukaryotes. Kramer J, et al. Cell Cycle, 2003 May-Jun. PMID 12734416
    3. R. Scott Hawley. Hawley RS. Curr Biol, 2003 Dec 16. PMID 14680644
    4. Requiem for distributive segregation: achiasmate segregation in Drosophila females. Hawley RS, et al. Trends Genet, 1993 Sep. PMID 8236460
    5. Direct evidence of a role for heterochromatin in meiotic chromosome segregation. Dernburg AF, et al. Cell, 1996 Jul 12. PMID 8689681

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutations disrupt the segregation of achiasmate chromosomes during female meiosis
      Title: The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in distributive segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in distributive segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    abnormal X segregation
    Names
    Axs-PA
    CG9703-PA
    aberrant X segregation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16680089..16683895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057429.3 → NP_476777.1  abnormal X segregation [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97132
      Related
      FBpp0074146, FBtr0074372
      Conserved Domains (1) summary
      pfam04547
      Location:202 → 623
      Anoctamin; Calcium-activated chloride channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97132 O97132

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