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    CG5246 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5246provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038484
    Locus tag
    Dmel_CG5246
    See related
    AllianceGenome:FB:FBgn0038484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP06628; Dmel\CG5246; SP96
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5246 in Genome Data Viewer
    Location:
    89F1-89F1; 3-60 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17136111..17137195)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12961833..12962917)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dietary Supplementation with Milk Lipids Leads to Suppression of Developmental and Behavioral Phenotypes of Hyperexcitable Drosophila Mutants. Kasuya J, et al. Neuroscience, 2023 Jun 1. PMID 37004908, Free PMC Article
    2. The progesterone antagonist mifepristone/RU486 blocks the negative effect on life span caused by mating in female Drosophila. Landis GN, et al. Aging (Albany NY), 2015 Jan. PMID 25614682, Free PMC Article
    3. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article
    4. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
    5. Drosophila microbiota modulates host metabolic gene expression via IMD/NF-κB signaling. Erkosar B, et al. PLoS One, 2014. PMID 24733183, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5246-PA
    NP_650603.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17136111..17137195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142346.3 → NP_650603.1  uncharacterized protein Dmel_CG5246 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650603.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEM6
      Related
      FBpp0082846
      Conserved Domains (2) summary
      smart00020
      Location:41 → 261
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:42 → 263
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS71 Q8MS71
    Q9VEM6 Q9VEM6

    Gene LinkOut

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