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    CG4709 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4709provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032169
    Locus tag
    Dmel_CG4709
    See related
    AllianceGenome:FB:FBgn0032169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4709; ZGPAT
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in spermatozoon. Orthologous to human ZGPAT (zinc finger CCCH-type and G-patch domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4709 in Genome Data Viewer
    Location:
    30F2-30F2; 2-38 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9954325..9956176)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9954325..9956176)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45949 Neighboring gene mir-87 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44872 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Thimgan MS, et al. Sleep, 2015 May 1. PMID 25409104, Free PMC Article
    2. The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub. Kwong PN, et al. J Biol Chem, 2015 Dec 11. PMID 26483546, Free PMC Article
    3. Comparative genomics and evolution of proteins involved in RNA metabolism. Anantharaman V, et al. Nucleic Acids Res, 2002 Apr 1. PMID 11917006, Free PMC Article
    4. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4709-PA
    CG4709-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9954325..9956176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298859.1 → NP_001285788.1  uncharacterized protein Dmel_CG4709, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285788.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VL59
      UniProtKB/TrEMBL
      X2JA03
      Conserved Domains (2) summary
      smart00356
      Location:155 → 176
      ZnF_C3H1; zinc finger
      pfam01585
      Location:312 → 355
      G-patch; G-patch domain

    2. NM_135487.4 → NP_609331.1  uncharacterized protein Dmel_CG4709, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609331.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VL59
      UniProtKB/TrEMBL
      X2JA03
      Related
      FBpp0079480
      Conserved Domains (2) summary
      smart00356
      Location:155 → 176
      ZnF_C3H1; zinc finger
      pfam01585
      Location:312 → 355
      G-patch; G-patch domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL59.1 Q9VL59
    X2JA03 X2JA03

    Gene LinkOut

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