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    Alg3 ALG3, alpha-1,3- mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg3provided by FlyBase
    Official Full Name
    ALG3, alpha-1,3- mannosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011297
    Locus tag
    Dmel_CG4084
    See related
    AllianceGenome:FB:FBgn0011297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1(2) not; alg3; ALG3; cDNA 10F; CG4084; dAlg3; Dmel\CG4084; l(2)not; L(2)NOT; l(2)td; l(2)tid; l(2)tud; NOT; ntid; tid
    Summary
    Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Involved in negative regulation of tumor necrosis factor-mediated signaling pathway. Predicted to be active in endoplasmic reticulum. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Orthologous to human ALG3 (ALG3 alpha-1,3- mannosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alg3 in Genome Data Viewer
    Location:
    59F6-59F6; 2-104 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23705439..23709792, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19592962..19597315, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred Neighboring gene lethal-(2)-denticleless Neighboring gene antisense RNA:CR45326 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sestrin Neighboring gene long non-coding RNA:CR45325 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic, cytogenetic and developmental analysis of the Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (1(2)tid). Kurzik-Dumke U, et al. Differentiation, 1992 Oct. PMID 1473626
    2. Sequential cleavage of the proteins encoded by HNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, results in products acting in distinct cellular compartments. Hacker B, et al. Hum Mol Genet, 2018 Dec 15. PMID 30192950
    3. Mitochondrial localization and temporal expression of the Drosophila melanogaster DnaJ homologous tumor suppressor Tid50. Kurzik-Dumke U, et al. Cell Stress Chaperones, 1998 Mar. PMID 9585178, Free PMC Article
    4. Gene within gene configuration and expression of the Drosophila melanogaster genes lethal(2) neighbour of tid [l(2)not] and lethal(2) relative of tid[l(2)rot]. Kurzik-Dumke U, et al. Gene, 1997 Oct 24. PMID 9373138
    5. Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog. Kurzik-Dumke U, et al. Dev Genet, 1995. PMID 7758246

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ALG3, alpha-1,3- mannosyltransferase
    Names
    Alg3-PA
    Asparagine-Linked Glycosylation-3
    CG4084-PA
    alpha1,3-mannosyltransferase
    l(2)tumorous disc
    l(2)tumorous imaginal discs
    lethal (2) neighbor of tid
    lethal(2) neighbour of 1(2)tid
    lethal(2) tumorous imaginal discs
    lethal(2)neighbour of tid
    lethal(2)tumorous imaginal discs
    tumorous imaginal disc
    NP_523829.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23705439..23709792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079105.4 → NP_523829.2  ALG3, alpha-1,3- mannosyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523829.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02532, O02533, Q24419, Q24420, Q24421, Q24607, Q27333, Q95R76, Q9W1K8
      UniProtKB/TrEMBL
      C4IXX8
      Related
      FBpp0072004
      Conserved Domains (1) summary
      pfam05208
      Location:51 → 470
      ALG3; ALG3 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82149.1 P82149
    Q27333.1 Q27333

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