ClC-c Chloride channel-c [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ClC-cprovided by FlyBase
Official Full Name: Chloride channel-cprovided by FlyBase
Primary source: FLYBASE:FBgn0036566
Locus tag: Dmel_CG5284
See related: AllianceGenome:FB:FBgn0036566
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0138359.7; CG5284; clc-c; Clc-c; ClCc; DmClC-c; DmClCc; Dmel\CG5284
Summary: Enables chloride:proton antiporter activity. Involved in chloride transmembrane transport; endosomal lumen acidification; and renal system process. Located in early endosome and recycling endosome. Is expressed in adult head. Used to study low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Human ortholog(s) of this gene implicated in Dent disease 1; Raynaud-Claes syndrome; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to several human genes including CLCN4 (chloride voltage-gated channel 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 72D5-72D5; 3-44 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16090454..16096151)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16083554..16089251)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila ClC-c Is a Homolog of Human CLC-5 and a New Model for Dent Disease Type 1.
Title: Drosophila ClC-c Is a Homolog of Human CLC-5 and a New Model for Dent Disease Type 1.
ClC-c regulates the proliferation of intestinal stem cells via the EGFR signalling pathway in Drosophila.
Title: ClC-c regulates the proliferation of intestinal stem cells via the EGFR signalling pathway in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chloride channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in endosomal lumen acidification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal system process	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chloride channel-c

Names: CG5284-PB; CG5284-PC; CG5284-PD; ClC-c-PB; ClC-c-PC; ClC-c-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

16090454..16096151

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274993.1 → NP_001261922.1 chloride channel-c, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261922.1

Status: REVIEWED

UniProtKB/TrEMBL

C9QP60, H5V8F7, Q9VUY1

Conserved Domains (4) summary

COG0517
Location:738 → 876

CBS; CBS domain [Signal transduction mechanisms]

cd03684
Location:215 → 719

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:741 → 878

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:298 → 699

Voltage_CLC; Voltage gated chloride channel
NM_168650.2 → NP_730105.3 chloride channel-c, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730105.3

Status: REVIEWED

UniProtKB/TrEMBL

C9QP60, H5V8F7, Q9VUY1

Conserved Domains (4) summary

COG0517
Location:738 → 876

CBS; CBS domain [Signal transduction mechanisms]

cd03684
Location:215 → 719

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:741 → 878

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:298 → 699

Voltage_CLC; Voltage gated chloride channel
NM_140577.2 → NP_648834.1 chloride channel-c, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648834.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IQN2, Q8MQK2

Related

FBpp0075201

Conserved Domains (4) summary

COG0517
Location:667 → 805

CBS; CBS domain [Signal transduction mechanisms]

cd03684
Location:144 → 648

ClC_3_like; ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has ...

cd04591
Location:670 → 807

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:227 → 628

Voltage_CLC; Voltage gated chloride channel