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    Tm2 Tropomyosin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tm2provided by FlyBase
    Official Full Name
    Tropomyosin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0004117
    Locus tag
    Dmel_CG4843
    See related
    AllianceGenome:FB:FBgn0004117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4843; Dmel\CG4843; dro Tm; DROTROPI1; Ifm(3)3; Ifm(3)5; Ifm-TmI; IP16005p; l(3)nc99Eb; mTmI; Tm; Tm127; TM2; TmI; TmII; Tn-H
    Summary
    Predicted to enable actin filament binding activity. Involved in heart development and positive regulation of sarcomere organization. Predicted to be active in actin filament. Is expressed in several structures, including adult heart; follicle cell; larval muscle system; muscle cell; and organism subdivision. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; distal arthrogryposis type 1A; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 3; and nemaline myopathy 4. Orthologous to human TPM1 (tropomyosin 1) and TPM2 (tropomyosin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tm2 in Genome Data Viewer
    Location:
    88E13-88E13; 3-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15310193..15315197)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11135915..11140919)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene lethal (3) neo43 Neighboring gene MORF-related gene 15 Neighboring gene Tropomyosin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic rescue of muscle defects associated with a mutant Drosophila melanogaster tropomyosin allele. Fyrberg EA, et al. Mol Cell Biol, 1987 Aug. PMID 2823110, Free PMC Article
    2. A pathogenic mechanism associated with myopathies and structural birth defects involves TPM2-directed myogenesis. McAdow J, et al. JCI Insight, 2022 Jun 22. PMID 35579956, Free PMC Article
    3. Effects of tropomyosin deficiency in flight muscle of Drosophila melanogaster. Molloy J, et al. Adv Exp Med Biol, 1993. PMID 8109330
    4. Developmental regulation of the Drosophila Tropomyosin I (TmI) gene is controlled by a muscle activator enhancer region that contains multiple cis-elements and binding sites for multiple proteins. Lin SC, et al. Dev Genet, 1997. PMID 9254904
    5. Cloning and analysis of the dec-1 female-sterile locus, a gene required for proper assembly of the Drosophila eggshell. Hawley RJ, et al. Genes Dev, 1988 Mar. PMID 3378704

    See all (150) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of sarcomere organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tropomyosin 2
    Names
    CG4843-PA
    CG4843-PB
    CG4843-PC
    CG4843-PE
    CG4843-PF
    CG4843-PG
    Tm2-PA
    Tm2-PB
    Tm2-PC
    Tm2-PE
    Tm2-PF
    Tm2-PG
    Tropomyosin-2
    lethal(3)nc99Eb
    tropomyosin
    tropomyosin 127
    tropomyosin I
    tropomyosin2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15310193..15315197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079637.5 → NP_524361.4  tropomyosin 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524361.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ9
      Related
      FBpp0082535
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 281
      Tropomyosin

    2. NM_169645.4 → NP_732013.2  tropomyosin 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732013.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0AVW5, A4V2Y6, P09490, P09491, Q24408, Q24427, Q24428, Q8SZ65, Q9VF95
      UniProtKB/TrEMBL
      H1UUJ7
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    3. NM_001275664.1 → NP_001262593.1  tropomyosin 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262593.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ9
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 281
      Tropomyosin

    4. NM_169644.2 → NP_732012.1  tropomyosin 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ9
      Related
      FBpp0082536
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 281
      Tropomyosin

    5. NM_001275663.1 → NP_001262592.1  tropomyosin 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262592.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ9
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 281
      Tropomyosin

    6. NM_001300408.1 → NP_001287337.1  tropomyosin 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287337.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ9
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 281
      Tropomyosin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHJ9 A0A0B4KHJ9
    P09491.1 P09491

    Gene LinkOut

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