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    CLUH clustered mitochondria homolog [ Homo sapiens (human) ]

    Gene ID: 23277, updated on 10-Dec-2024

    Summary

    Official Symbol
    CLUHprovided by HGNC
    Official Full Name
    clustered mitochondria homologprovided by HGNC
    Primary source
    HGNC:HGNC:29094
    See related
    Ensembl:ENSG00000132361 MIM:616184; AllianceGenome:HGNC:29094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLU1
    Summary
    Enables mRNA binding activity. Involved in intracellular distribution of mitochondria. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 25.8), duodenum (RPKM 18.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CLUH in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (2689387..2712020, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (2578517..2601136, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2592681..2615314, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene platelet activating factor acetylhydrolase 1b regulatory subunit 1 Neighboring gene RNA, 7SL, cytoplasmic 608, pseudogene Neighboring gene uncharacterized LOC105371490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2594504-2595012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2595013-2595520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2603508-2604008 Neighboring gene microRNA 6776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2610047-2610943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2614531-2615427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2615428-2616323 Neighboring gene uncharacterized LOC105371592 Neighboring gene coiled-coil domain containing 92B Neighboring gene microRNA 1253

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ23672, KIAA0664, DKFZp686L05242, DKFZp686M09233

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA binding  
    enables mRNA binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    clustered mitochondria protein homolog
    Names
    clustered mitochondria (cluA/CLU1) homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366661.1 → NP_001353590.1  clustered mitochondria protein homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005696
      Consensus CDS
      CCDS92221.1
      UniProtKB/TrEMBL
      A0A494C0R8, I3L2B0
      Related
      ENSP00000498679.1, ENST00000651024.2
      Conserved Domains (5) summary
      sd00006
      Location:1061 → 1087
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:806 → 987
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:394 → 614
      CLU; Clustered mitochondria
      pfam13424
      Location:1141 → 1216
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:104 → 177
      CLU_N; Mitochondrial function, CLU-N-term
    2. NM_001366662.1 → NP_001353591.1  clustered mitochondria protein homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005696
      Consensus CDS
      CCDS92220.1
      UniProtKB/Swiss-Prot
      O75153, Q6AHY2, Q6P3X7, Q6ZUG8, Q8N4U7, Q9BTA3, Q9H979
      UniProtKB/TrEMBL
      K7EIG1
      Related
      ENSP00000458986.1, ENST00000570628.6
      Conserved Domains (5) summary
      sd00006
      Location:1022 → 1048
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:767 → 948
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:356 → 576
      CLU; Clustered mitochondria
      pfam13424
      Location:1102 → 1177
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:66 → 139
      CLU_N; Mitochondrial function, CLU-N-term
    3. NM_015229.4 → NP_056044.4  clustered mitochondria protein homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB014564, AC005696, AK125717, AW291521, BC033614, HY024625
      Consensus CDS
      CCDS45572.1
      UniProtKB/TrEMBL
      I3L2B0
      Conserved Domains (5) summary
      sd00006
      Location:1060 → 1086
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:805 → 986
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:394 → 614
      CLU; Clustered mitochondria
      pfam13424
      Location:1140 → 1215
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:104 → 177
      CLU_N; Mitochondrial function, CLU-N-term

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      2689387..2712020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435694.1 → XP_047291650.1  clustered mitochondria protein homolog isoform X4

      UniProtKB/Swiss-Prot
      O75153, Q6AHY2, Q6P3X7, Q6ZUG8, Q8N4U7, Q9BTA3, Q9H979
      UniProtKB/TrEMBL
      K7EIG1
      Related
      ENSP00000388872.1, ENST00000435359.5
    2. XM_011523768.4 → XP_011522070.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      K7EIG1
      Conserved Domains (5) summary
      sd00006
      Location:1023 → 1049
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:768 → 949
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:356 → 576
      CLU; Clustered mitochondria
      pfam13424
      Location:1103 → 1178
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:66 → 139
      CLU_N; Mitochondrial function, CLU-N-term
    3. XM_024450679.2 → XP_024306447.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      K7EIG1
      Conserved Domains (5) summary
      sd00006
      Location:1023 → 1049
      TPR; TPR repeat [structural motif]
      pfam12807
      Location:768 → 949
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:356 → 576
      CLU; Clustered mitochondria
      pfam13424
      Location:1103 → 1178
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:66 → 139
      CLU_N; Mitochondrial function, CLU-N-term
    4. XM_047435695.1 → XP_047291651.1  clustered mitochondria protein homolog isoform X4

      UniProtKB/Swiss-Prot
      O75153, Q6AHY2, Q6P3X7, Q6ZUG8, Q8N4U7, Q9BTA3, Q9H979
      UniProtKB/TrEMBL
      K7EIG1
    5. XM_047435693.1 → XP_047291649.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      K7EIG1
    6. XM_024450676.2 → XP_024306444.2  clustered mitochondria protein homolog isoform X2

      UniProtKB/TrEMBL
      I3L2B0
    7. XM_024450675.2 → XP_024306443.2  clustered mitochondria protein homolog isoform X1

      UniProtKB/TrEMBL
      I3L2B0
    8. XM_047435692.1 → XP_047291648.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      K7EIG1
      Related
      ENSP00000464732.2, ENST00000575014.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      2578517..2601136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315602.1 → XP_054171577.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      K7EIG1
    2. XM_054315606.1 → XP_054171581.1  clustered mitochondria protein homolog isoform X4

      UniProtKB/Swiss-Prot
      O75153, Q6AHY2, Q6P3X7, Q6ZUG8, Q8N4U7, Q9BTA3, Q9H979
      UniProtKB/TrEMBL
      K7EIG1
    3. XM_054315601.1 → XP_054171576.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      K7EIG1
    4. XM_054315605.1 → XP_054171580.1  clustered mitochondria protein homolog isoform X4

      UniProtKB/Swiss-Prot
      O75153, Q6AHY2, Q6P3X7, Q6ZUG8, Q8N4U7, Q9BTA3, Q9H979
      UniProtKB/TrEMBL
      K7EIG1
    5. XM_054315600.1 → XP_054171575.1  clustered mitochondria protein homolog isoform X6

      UniProtKB/TrEMBL
      I3L2B0
    6. XM_054315603.1 → XP_054171578.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      K7EIG1
    7. XM_054315599.1 → XP_054171574.1  clustered mitochondria protein homolog isoform X5

      UniProtKB/TrEMBL
      I3L2B0
    8. XM_054315604.1 → XP_054171579.1  clustered mitochondria protein homolog isoform X3

      UniProtKB/TrEMBL
      K7EIG1
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