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    ZNF559-ZNF177 ZNF559-ZNF177 readthrough [ Homo sapiens (human) ]

    Gene ID: 100529215, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF559-ZNF177provided by HGNC
    Official Full Name
    ZNF559-ZNF177 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:42964
    See related
    Ensembl:ENSG00000270011 AllianceGenome:HGNC:42964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19. Alternative splicing results in multiple transcript variants, which encode the ZNF177 protein due to either leaky scanning by ribosomes, or absence of the ZNF559 start codon. [provided by RefSeq, Jan 2011]
    Expression
    Broad expression in testis (RPKM 5.0), ovary (RPKM 3.1) and 22 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF559-ZNF177 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9324179..9382617)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9450390..9508854)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9434855..9493293)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily H member 1 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr19:9406829-9407424 Neighboring gene zinc finger protein 699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13927 Neighboring gene Sharpr-MPRA regulatory region 15409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10038 Neighboring gene zinc finger protein 559 Neighboring gene UBXN2A pseudogene 1 Neighboring gene zinc finger protein 177 Neighboring gene uncharacterized LOC112268250 Neighboring gene zinc finger protein 266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13929

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Repetitive elements in the 5' untranslated region of a human zinc-finger gene modulate transcription and translation efficiency. Landry JR, et al. Genomics, 2001 Aug. PMID 11549323
    2. Transcripts from a novel human KRAB zinc finger gene contain spliced Alu and endogenous retroviral segments. Baban S, et al. Genomics, 1996 May 1. PMID 8661005
    3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
    4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
    5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 177

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172650.3 → NP_001166121.1  zinc finger protein 177 isoform b

      See identical proteins and their annotated locations for NP_001166121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate exon structure in the 5' UTR, uses an alternate splice site that causes a frameshift in the 3' coding region, and lacks a segment of the 3' UTR, compared to variant 4. The resulting isoform (b) has a distinct and longer C-terminus, compared to isoform c. A non-read-through variant of the downstream ZNF177 gene, as represented by GeneID:7730, also encodes isoform b.
      Source sequence(s)
      AC011451, BC034489
      UniProtKB/Swiss-Prot
      Q13360
      Related
      ENSP00000445323.1, ENST00000541595.6
      Conserved Domains (4) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:87 → 282
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:126 → 146
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:279 → 303
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001202425.1 → NP_001189354.1  zinc finger protein 177 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longer transcript but encodes the shorter isoform (c).
      Source sequence(s)
      AC011451, BC034489, U37251
      UniProtKB/TrEMBL
      V9H066
      Related
      ENSP00000413568.2, ENST00000446085.8
      Conserved Domains (2) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      pfam01352
      Location:14 → 53
      KRAB; KRAB box

    3. NM_001384659.1 → NP_001371588.1  zinc finger protein 177 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC011451
      UniProtKB/Swiss-Prot
      B4DY57, E9PDG0, I3L0I4, Q13360, Q96ER2
      Conserved Domains (4) summary
      smart00349
      Location:14 → 70
      KRAB; krueppel associated box
      COG5048
      Location:212 → 442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:439 → 463
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      9324179..9382617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      9450390..9508854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13360.4 GenPept UniProtKB/Swiss-Prot:Q13360

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