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    AI5_ALPHA intron-encoded DNA endonuclease aI5 alpha [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AI5_ALPHA
    Official Full Name
    intron-encoded DNA endonuclease aI5 alpha
    Primary source
    SGD:S000007265
    Locus tag
    Q0070
    See related
    AllianceGenome:SGD:S000007265; FungiDB:Q0070; VEuPathDB:Q0070
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables endonuclease activity. Involved in movement of group I intron. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Orthologous to human MT-CO1 (mitochondrially encoded cytochrome c oxidase I). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AI5_ALPHA in Genome Data Viewer
    Sequence:
    Chromosome: MT; NC_001224.1 (13818..23167)

    Chromosome MT - NC_001224.1Genomic Context describing neighboring genes Neighboring gene 15S ribosomal RNA Neighboring gene tRNA-Trp Neighboring gene cytochrome c oxidase subunit 1 Neighboring gene intron-encoded reverse transcriptase aI1 Neighboring gene intron-encoded reverse transcriptase aI2 Neighboring gene intron-encoded DNA endonuclease aI3 Neighboring gene intron-encoded DNA endonuclease aI4 Neighboring gene intron-encoded DNA endonuclease aI5 beta Neighboring gene F1F0 ATP synthase subunit 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001224.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A map of the binding site for catalytic domain 5 in the core of a group II intron ribozyme. Konforti BB, et al. EMBO J, 1998 Dec 1. PMID 9843514, Free PMC Article
    2. Structure and activity of the mitochondrial intron-encoded endonuclease, I-SceIV. Wernette CM. Biochem Biophys Res Commun, 1998 Jul 9. PMID 9675098
    3. The yeast mitochondrial intron aI5 alpha: associated endonuclease activity and in vivo mobility. Séraphin B, et al. Gene, 1992 Apr 1. PMID 1314207
    4. The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. Foury F, et al. FEBS Lett, 1998 Dec 4. PMID 9872396
    5. A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase. Böttinger L, et al. Mol Biol Cell, 2013 Sep. PMID 23864706, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intron homing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in movement of group I intron IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    intron-encoded DNA endonuclease aI5 alpha
    NP_009306.1
    • Endonuclease I-SceIV; involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001224.1 Reference assembly

      Range
      13818..23167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_009306.1 intron-encoded DNA endonuclease aI5 alpha (mitochondrion) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009306.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A0A7NYD1, Q8W770, Q9ZZX1
      UniProtKB/TrEMBL
      G2HKD6
      Conserved Domains (3) summary
      pfam00115
      Location:13 → 325
      COX1; Cytochrome C and Quinol oxidase polypeptide I
      pfam03161
      Location:424 → 601
      LAGLIDADG_2; LAGLIDADG DNA endonuclease family
      cl00275
      Location:9 → 324
      Heme_Cu_Oxidase_I; Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZZX1.1

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