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    MAM1 Mam1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856843, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAM1
    Official Full Name
    Mam1p
    Primary source
    SGD:S000000908
    Locus tag
    YER106W
    See related
    AllianceGenome:SGD:S000000908; FungiDB:YER106W; VEuPathDB:YER106W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in meiotic sister chromatid cohesion involved in meiosis I and spindle attachment to meiosis I kinetochore. Located in kinetochore. Part of monopolin complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MAM1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (372326..373234)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Rtt105p Neighboring gene Nup157p Neighboring gene RNA export factor GLE2 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i. Tóth A, et al. Cell, 2000 Dec 22. PMID 11163190
    2. Evidence of Zip1 Promoting Sister Kinetochore Mono-orientation During Meiosis in Budding Yeast. Prajapati HK, et al. G3 (Bethesda), 2018 Nov 6. PMID 30254179, Free PMC Article
    3. Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex. Monje-Casas F, et al. Cell, 2007 Feb 9. PMID 17289568, Free PMC Article
    4. Molecular architecture of the yeast monopolin complex. Corbett KD, et al. Cell Rep, 2012 Jun 28. PMID 22813733, Free PMC Article
    5. Co-segregation of yeast plasmid sisters under monopolin-directed mitosis suggests association of plasmid sisters with sister chromatids. Liu YT, et al. Nucleic Acids Res, 2013 Apr. PMID 23423352, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Together, the Hrr25 central domain and Mam1 form a novel, contiguous embellishment to the Hrr25 kinase domain that affects Hrr25 conformational dynamics and enzyme kinetics.
      Title: Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.
    2. We show that monopolin subunit Mam1 binds tightly to Hrr25, a highly conserved casein kinase 1 delta/varepsilon, and recruits it to meiosis I centromeres. Hrr25 kinase activity and Mam1 binding are both essential for monopolar attachment.
      Title: Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.
    3. Study finds that the Aurora B kinase Ipl1 regulates kinetochore-microtubule attachment during both meiotic divisions and that a complex known as the monopolin complex ensures that the protein kinase coorients sister chromatids during meiosis I.
      Title: Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion involved in meiosis I IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion involved in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of monopolin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mam1p
    NP_011032.1
    • Monopolin; meiosis-specific kinetochore-associated protein involved in monopolar attachment of sister kinetochores to the meiotic spindle; subunit of monopolin, a complex that prevents biorientation of sister kinetochores to ensure homolog biorientation during meiosis I; regulates the conformation, enzyme kinetics and substrate specificity of the Dsn1p kinase, Hrr1p; expressed only during the first meiotic division

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      372326..373234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178997.1 → NP_011032.1  TPA: Mam1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011032.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM13, E9P8Y3, P40065
      UniProtKB/TrEMBL
      A6ZR62, C8Z7C4, G2WD17
      Conserved Domains (1) summary
      pfam10434
      Location:4 → 258
      MAM1; Monopolin complex protein MAM1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40065.1

    Gene LinkOut

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