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    DSE1 Dse1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DSE1
    Official Full Name
    Dse1p
    Primary source
    SGD:S000000926
    Locus tag
    YER124C
    See related
    AllianceGenome:SGD:S000000926; FungiDB:YER124C; VEuPathDB:YER124C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables G-protein beta/gamma-subunit complex binding activity. Involved in invasive growth in response to glucose limitation; regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion; and septum digestion after cytokinesis. Located in cellular bud neck. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DSE1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (407342..409063, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor GTPase-activating protein Neighboring gene casein kinase YCK3 Neighboring gene NEDD4 family E3 ubiquitin-protein ligase Neighboring gene rRNA-processing protein NSA2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deregulation of DSE1 gene expression results in aberrant budding within the birth scar and cell wall integrity pathway activation in Saccharomyces cerevisiae. Frydlová I, et al. Eukaryot Cell, 2009 Apr. PMID 19252124, Free PMC Article
    2. Dse1 may control cross talk between the pheromone and filamentation pathways in yeast. Draper E, et al. Curr Genet, 2009 Dec. PMID 19820940
    3. Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae. Ufano S, et al. J Cell Sci, 2004 Feb 1. PMID 14709718
    4. Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p. Doolin MT, et al. Mol Microbiol, 2001 Apr. PMID 11309124
    5. Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Colman-Lerner A, et al. Cell, 2001 Dec 14. PMID 11747810

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DSE1 binds both to a Gbetagamma-affinity column & to the shared MEKK, Ste11. The interaction of Dse1 with both Gbeta and Ste11 may be designed to control cross talk between the pheromone and filamentation pathways.
      Title: Dse1 may control cross talk between the pheromone and filamentation pathways in yeast.
    2. Deletion of the DSE1 gene suppressed cell wall integrity pathway and resulted in aberrant budding.
      Title: Deregulation of DSE1 gene expression results in aberrant budding within the birth scar and cell wall integrity pathway activation in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables G-protein beta/gamma-subunit complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dse1p
    NP_011050.3
    • Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      407342..409063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179014.3 → NP_011050.3  TPA: Dse1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011050.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM30, P40077
      UniProtKB/TrEMBL
      B3LRP0
      Conserved Domains (1) summary
      sd00039
      Location:217 → 252
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40077.1

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